McConnell O J, Longley R, Gunasekera M
Harbor Branch Oceanographic Institution, Inc., Ft. Pierce, FL 34946.
Experientia. 1992 Sep 15;48(9):891-2. doi: 10.1007/BF02118428.
Isometachromin (1), a new sesquiterpene-quinone that is related structurally to metachromin C (2), and the known compounds ilimaquinone (3) and 5-epi-ilimaquinone (4), were isolated from a deep water sponge in the family Spongiidae; the structure of isometachromin was elucidated by spectral methods. Isometachromin exhibits in vitro cytotoxicity against the human lung cancer cell line A549 (IC50 = 2.6 micrograms/ml), but not against P388 murine leukemia (IC 50 > or equal to 10 micrograms/ml) and also exhibits antimicrobial activity.
