Shen Y C, Hsieh P W
Institute of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, Republic of China.
J Nat Prod. 1997 Feb;60(2):93-7. doi: 10.1021/np9605302.
Two new sesquiterpene hydroquinones, polyfibrospongols A (1) and B (2), were isolated from the Taiwanese marine sponge Polyfibrospongia australis Lendenfeld (Spongiidae) in addition to the known metabolites, dictyoceratin A (3), ilimaquinone (4), and 5-epi-ilimaquinone (9). The structures of these compounds have been determined mainly on the basis of spectral and chemical methods. Biological testing revealed that compounds 1 and 2 exhibited significant cytotoxicity against human KB-16, A-549, and murine P-388 tumor cell lines.
除了已知的代谢产物双盘角海绵素A（3）、伊里马醌（4）和5-表伊里马醌（9）之外，还从台湾海洋海绵澳大利亚多纤维海绵（多纤维海绵科）中分离出两种新的倍半萜对苯二酚，多纤维海绵醇A（1）和B（2）。这些化合物的结构主要通过光谱和化学方法确定。生物测试表明，化合物1和2对人KB-16、A-549以及小鼠P-388肿瘤细胞系表现出显著的细胞毒性。
