Dixon D M, Merz W G, Elliott H L, Macleay S
Department of Biology, Loyola College, Baltimore, MD 21210.
Mycopathologia. 1987 Dec;100(3):145-53. doi: 10.1007/BF00437040.
Experimental central nervous system (CNS) phaeohyphomycosis was established in cortisone-treated mice following intranasal exposure to conidia of Xylohypha bantiana (Cladosporium bantianum, C. trichoides). X. bantiana was recovered from the lungs of 78% of intranasally inoculated normal mice sacrificed within the first 3 days of infection and from 15% at day 28. The fungus was not recovered from the brains of normal mice. In contrast, X. bantiana was recovered from only 33% of the lungs of cortisone-treated mice within the first 3 days of infection. However, the fungus was recovered from the brain of 11% of cortisone-treated mice sacrificed or dying over a 28 day period. Histologically and temporally the CNS disease in cortisone-treated, intranasally inoculated mice was consistent with hematogenous dissemination from a primary pulmonary focus.
在经皮质酮处理的小鼠中，通过鼻内暴露于班替木霉（班替枝孢霉、毛状枝孢霉）的分生孢子建立了实验性中枢神经系统（CNS）暗色丝孢霉病。在感染的前3天内处死的经鼻接种的正常小鼠中，78%的小鼠肺部可分离到班替木霉，在第28天时为15%。正常小鼠的大脑中未分离到该真菌。相比之下，在感染的前3天内，经皮质酮处理的小鼠中只有33%的小鼠肺部可分离到班替木霉。然而，在28天内处死或死亡的经皮质酮处理的小鼠中，11%的小鼠大脑中可分离到该真菌。组织学和时间上，经皮质酮处理、经鼻接种的小鼠的中枢神经系统疾病与原发性肺部病灶的血行播散一致。
