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白血病缓解期患者对与急性髓细胞白血病相关抗原产生反应的进一步证据。

Further evidence of response by leukaemia patients in remission to antigen(s) related to acute myelogenous leukaemia.

作者信息

Cocks P, Powles R L, Chapuis B, Alexander P

出版信息

Br J Cancer. 1977 Mar;35(3):273-9. doi: 10.1038/bjc.1977.39.

DOI:10.1038/bjc.1977.39

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2025280/

Abstract

Fifteen patients with acute myelogenous leukaemia were studied to determine if their remission blood leucocytes could be stimulated into taking up [3H] thymidine after in vitro culture with their own cryo-preserved irradiated AML leukaemia cells. In 6/15 patients it was possible to show autologous recognition and equal recognition of their stored leukaemia cells, even when they had previously been maintained in in vitro proliferative cultures in liquid suspension and undergoing myeloid maturation for one week. After in vitro proliferative culture, 4 populations of leukaemia cells produced material in the supernatant media between 3 and 7 days capable of inducing [3H] thymidine uptake in autologous (2 pts, 5 supernatants) and allogeneic (2 pts, 2 supernatants) AML remission lymphocytes, but not in normal donor lymphocytes. The relevance of these observations to tumour-associated AML antigen is discussed.

摘要

对15例急性髓性白血病患者进行了研究，以确定其缓解期血液中的白细胞在与自身冷冻保存并经照射的急性髓性白血病（AML）白血病细胞进行体外培养后，是否能被刺激摄取[3H]胸苷。在15例患者中的6例中，即使这些患者先前在液体悬浮液中进行体外增殖培养并经历髓系成熟一周，仍有可能显示出对其储存的白血病细胞的自体识别和同等识别。体外增殖培养后，4个白血病细胞群体在3至7天之间在上清培养基中产生了能够诱导自体（2例患者，5份上清液）和同种异体（2例患者，2份上清液）AML缓解期淋巴细胞摄取[3H]胸苷的物质，但不能诱导正常供体淋巴细胞摄取。讨论了这些观察结果与肿瘤相关AML抗原的相关性。