Hill P, Chan P, Cohen L, Wynder E, Kuno K
Cancer. 1977 Apr;39(4 Suppl):1820-6. doi: 10.1002/1097-0142(197704)39:4+<1820::aid-cncr2820390813>3.0.co;2-6.
In women, dietary modification and life style affect the risk of breast cancer and may alter the hormonal status, while in experimental animals diet can alter the incidence of induced mammary tumors. In this study, a high fat diet increased the incidence of DMBA-induced tumors in rats while this increase in incidence was lowered and the effect of a high fat diet obliterated by an anti-prolactin during CB154. Premenopausal Japanese women had a higher estradiol level than their Caucasian counterpart. In Japanese but not Caucasian breast cancer patients, the estradiol decreased. When nurses were transferred from the Western to a vegetarian diet, the menstrual cycle was shortened, while their prolactin and testosterone decreased. Data indicate that dietary factors influence tumor incidence and hormone profile in rat mammary cancer and the hormonal status in women.
在女性中，饮食调整和生活方式会影响患乳腺癌的风险，并且可能改变激素状态，而在实验动物中，饮食可改变诱发乳腺肿瘤的发生率。在本研究中，高脂饮食增加了大鼠中DMBA诱发肿瘤的发生率，而在CB154期间，抗催乳素降低了这种发生率的增加，并消除了高脂饮食的影响。绝经前日本女性的雌二醇水平高于她们的白种人同龄人。在日本乳腺癌患者而非白种人乳腺癌患者中，雌二醇水平下降。当护士从西方饮食改为素食时，月经周期缩短，同时她们的催乳素和睾酮水平降低。数据表明，饮食因素影响大鼠乳腺癌的肿瘤发生率和激素谱以及女性的激素状态。
