Punnonen K, Hietanen E, Auvinen O, Punnonen R
Department of Physiology, University of Turku, Finland.
J Cancer Res Clin Oncol. 1989;115(6):575-8. doi: 10.1007/BF00391361.
The fatty acid composition of fractionated phospholipids and neutral lipids was analyzed in human breast cancer tissues and the surrounding, apparently healthy tissue. In the cancer tissues the relative amounts of unsaturated fatty acids were increased in all the phospholipid subclasses analyzed. The differences were more marked in phosphatidylethanolamine than in the other phospholipid fractions and, furthermore, the relative amount of phosphatidyl-ethanolamine was increased in cancerous tissue. In blood-erythrocyte phospholipids, no differences in fatty acid composition could be found between breast cancer and control patients. The present study suggests that the lipid composition of cancerous breast tissues differs from that of the surrounding tissue and may be involved in carcinogenesis.
对人乳腺癌组织及其周围看似健康的组织中分离出的磷脂和中性脂质的脂肪酸组成进行了分析。在癌组织中，所有分析的磷脂亚类中不饱和脂肪酸的相对含量均有所增加。磷脂酰乙醇胺中的差异比其他磷脂组分更为明显，此外，癌组织中磷脂酰乙醇胺的相对含量增加。在血红细胞磷脂中，乳腺癌患者与对照患者之间未发现脂肪酸组成的差异。本研究表明，癌性乳腺组织的脂质组成与周围组织不同，可能参与了致癌过程。
