骨髓移植作为治疗KK-Ay小鼠非胰岛素依赖型糖尿病的一种策略。
Bone marrow transplantation as a strategy for treatment of non-insulin-dependent diabetes mellitus in KK-Ay mice.
作者信息
Than S, Ishida H, Inaba M, Fukuba Y, Seino Y, Adachi M, Imura H, Ikehara S
机构信息
First Department of Pathology, Kansai Medical University, Osaka, Japan.
出版信息
J Exp Med. 1992 Oct 1;176(4):1233-8. doi: 10.1084/jem.176.4.1233.
Abstract
The effects of allogeneic bone marrow transplantation (BMT) on non-insulin-dependent diabetes mellitus (NIDDM) were examined using KK-Ay mice. KK-Ay mice reconstituted with KK-Ay bone marrow cells showed glycosuria, hyperinsulinemia, and hyperlipidemia. However, KK-Ay mice (H-2b) that had been lethally irradiated (9.0 Gy) and then reconstituted with T cell-depleted bone marrow cells from normal BALB/c mice (H-2d) showed negative urine sugar with decreases in serum insulin and lipid levels 4 mo after BMT. Morphological recovery of islets and glomeruli was also noted after allogeneic BMT. These findings suggest that BMT can be used to treat not only a certain type of NIDDM but also its complications such as hyperlipidemia and diabetic nephropathy.
摘要
使用KK-Ay小鼠研究了同种异体骨髓移植（BMT）对非胰岛素依赖型糖尿病（NIDDM）的影响。用KK-Ay骨髓细胞重建的KK-Ay小鼠出现糖尿、高胰岛素血症和高脂血症。然而，接受9.0 Gy致死剂量照射后，再用来自正常BALB/c小鼠（H-2d）的T细胞去除的骨髓细胞重建的KK-Ay小鼠（H-2b），在BMT后4个月尿糖呈阴性，血清胰岛素和脂质水平降低。同种异体BMT后还观察到胰岛和肾小球的形态学恢复。这些发现表明，BMT不仅可用于治疗某种类型的NIDDM，还可用于治疗其并发症，如高脂血症和糖尿病肾病。
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