Le Guenno B, Pison G, Enel C, Lagarde E, Seck C
Institut Pasteur, Dakar, Senegal.
J Med Virol. 1992 Sep;38(1):67-70. doi: 10.1002/jmv.1890380114.
In a community study in rural Senegal, 22 human immunodeficiency virus type-2 (HIV-2) seropositive cases and 64 matched controls were examined clinically and evaluated immunologically. The presence of clinical signs was highly correlated with HIV-2 seropositivity: 9 anti-HIV-2 positive patients and 5 controls presented with clinical signs (odd ratio [OR] = 8.2, confidence limits [CL] 2-35). The main symptom associated with HIV-2 seropositivity was a chronic cough (OR = 18.5, CL 1.8-899). The presence of diarrhoea was not significant (OR = 3.1, CL 0.3-3.5). The total number of CD8 cells, CD4/CD8 ratio, beta 2 microglobulin, and IgG level discriminated between seropositive and seronegative individuals (P less than 0.05). When the anti-HIV-2 positives were grouped as 13 healthy and 9 sick people, red blood cells, lymphocytes, T lymphocytes, CD4 cells, and beta 2 microglobulin differed significantly. Clinical symptoms were associated with immunodepression: 5 of 14 sick people had less than 500 CD4/microliters vs. 1 of 72 healthy persons. This study at the community level emphasizes the clinical and immunological impact of HIV-2 infection. Even if it presents with a longer incubation period than HIV-1, this virus is a major threat to public health.
在塞内加尔农村进行的一项社区研究中，对22例2型人类免疫缺陷病毒（HIV-2）血清阳性病例和64例匹配对照进行了临床检查和免疫评估。临床症状的出现与HIV-2血清阳性高度相关：9例抗HIV-2阳性患者和5例对照有临床症状（比值比[OR]=8.2，置信区间[CL]2-35）。与HIV-2血清阳性相关的主要症状是慢性咳嗽（OR=18.5，CL 1.8-899）。腹泻的出现无统计学意义（OR=3.1，CL 0.3-3.5）。CD8细胞总数、CD4/CD8比值、β2微球蛋白和IgG水平可区分血清阳性和血清阴性个体（P<0.05）。当抗HIV-2阳性者分为13例健康者和9例患病者时，红细胞、淋巴细胞、T淋巴细胞、CD4细胞和β2微球蛋白有显著差异。临床症状与免疫抑制有关：14例患病者中有5例CD4细胞计数低于500/微升，而72例健康者中只有1例。这项社区层面的研究强调了HIV-2感染的临床和免疫影响。即使它的潜伏期比HIV-1长，这种病毒对公共卫生也是一个重大威胁。
