Foy P M, Chadwick D W, Rajgopalan N, Johnson A L, Shaw M D
Mersey Regional Department of Medical and Surgical Neurology, Walton Hospital, Liverpool.
J Neurol Neurosurg Psychiatry. 1992 Sep;55(9):753-7. doi: 10.1136/jnnp.55.9.753.
A total of 276 patients with a high risk of developing postoperative seizures were randomised to treatment with carbamazepine or phenytoin for six or 24 months, or to no treatment. No significant differences were found (though the confidence limits were fairly wide) between the regimes in respect of the incidence of seizures or death. In a substantial proportion of the patients postoperative epilepsy remained a continuing disability. A high incidence of drug-related side effects was found in the treatment groups. Prophylactic anticonvulsants cannot therefore be recommended routinely following supratentorial craniotomy.
共有276例有术后癫痫发作高风险的患者被随机分为卡马西平组、苯妥英钠组，分别接受6个月或24个月的治疗，或不接受治疗。在癫痫发作发生率或死亡率方面，各治疗方案之间未发现显著差异（尽管置信区间相当宽）。相当一部分患者术后癫痫仍持续存在。在治疗组中发现药物相关副作用的发生率很高。因此，幕上开颅术后不能常规推荐预防性使用抗惊厥药物。
