预防性抗惊厥药物会改变开颅术后的癫痫发作模式吗？
Do prophylactic anticonvulsant drugs alter the pattern of seizures after craniotomy?
作者信息
Foy P M, Chadwick D W, Rajgopalan N, Johnson A L, Shaw M D
机构信息
Mersey Regional Department of Medical and Surgical Neurology, Walton Hospital, Liverpool.
出版信息
J Neurol Neurosurg Psychiatry. 1992 Sep;55(9):753-7. doi: 10.1136/jnnp.55.9.753.
Abstract
A total of 276 patients with a high risk of developing postoperative seizures were randomised to treatment with carbamazepine or phenytoin for six or 24 months, or to no treatment. No significant differences were found (though the confidence limits were fairly wide) between the regimes in respect of the incidence of seizures or death. In a substantial proportion of the patients postoperative epilepsy remained a continuing disability. A high incidence of drug-related side effects was found in the treatment groups. Prophylactic anticonvulsants cannot therefore be recommended routinely following supratentorial craniotomy.
摘要
共有276例有术后癫痫发作高风险的患者被随机分为卡马西平组、苯妥英钠组，分别接受6个月或24个月的治疗，或不接受治疗。在癫痫发作发生率或死亡率方面，各治疗方案之间未发现显著差异（尽管置信区间相当宽）。相当一部分患者术后癫痫仍持续存在。在治疗组中发现药物相关副作用的发生率很高。因此，幕上开颅术后不能常规推荐预防性使用抗惊厥药物。
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本文引用的文献
1
The natural history of postoperative seizures.
Acta Neurochir (Wien). 1981;57(1-2):15-22. doi: 10.1007/BF01665108.
2
The incidence of postoperative seizures.术后癫痫发作的发生率。
Acta Neurochir (Wien). 1981;55(3-4):253-64. doi: 10.1007/BF01808441.
3
The effectiveness of prophylactic anticonvulsants following neurosurgery.神经外科手术后预防性抗惊厥药物的疗效。
Acta Neurochir (Wien). 1983;69(3-4):253-8. doi: 10.1007/BF01401812.
4
Phenytoin and postoperative epilepsy. A double-blind study.苯妥英钠与术后癫痫。一项双盲研究。
J Neurosurg. 1983 May;58(5):672-7. doi: 10.3171/jns.1983.58.5.0672.
5
Serum anticonvulsant concentrations and the risk of drug induced skin eruptions.血清抗惊厥药物浓度与药物性皮肤疹风险
J Neurol Neurosurg Psychiatry. 1984 Jun;47(6):642-4. doi: 10.1136/jnnp.47.6.642.
6
Early treatment and prognosis of epilepsy.癫痫的早期治疗与预后
Epilepsia. 1987 Mar-Apr;28(2):97-106. doi: 10.1111/j.1528-1157.1987.tb03633.x.
7
Anticonvulsant prophylaxis in neurosurgery.神经外科手术中的抗惊厥预防
Br J Neurosurg. 1989;3(4):425-7. doi: 10.3109/02688698909002827.
8
A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures.一项关于苯妥英钠预防创伤后癫痫发作的随机双盲研究。
N Engl J Med. 1990 Aug 23;323(8):497-502. doi: 10.1056/NEJM199008233230801.
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