Takahashi Y, Ishii N, Lue T F, Tanagho E A
Department of Urology, University of California School of Medicine, San Francisco.
J Urol. 1992 Oct;148(4):1323-5. doi: 10.1016/s0022-5347(17)36901-x.
We investigated the hemodynamic effects of intracavernous injection of adenosine on canine penile erection. In all ten dogs studied, adenosine induced a dose-dependent increase of intracavernous pressure (ICP). Adenosine (0.67 to 15 micrograms/kg., B.W.) increased arterial blood flow by 83 to 325 percent above baseline levels and also increased venous resistance, which resulted in a full erection (ICP = 80 to 140 cm. H2O) for one to 7 minutes. The repeatability of the adenosine effect was confirmed in eight dogs. We found that adenosine, by virtue of its smooth muscle relaxation properties, can induce a dose-dependent increase of ICP and cause a full erection in dogs.
我们研究了海绵体内注射腺苷对犬阴茎勃起的血流动力学影响。在所有十只受试犬中，腺苷可引起海绵体内压（ICP）呈剂量依赖性升高。腺苷（0.67至15微克/千克，体重）使动脉血流量比基线水平增加83%至325%，同时也增加了静脉阻力，从而导致完全勃起（ICP = 80至140厘米水柱）持续1至7分钟。八只犬的实验证实了腺苷作用的可重复性。我们发现，腺苷凭借其平滑肌舒张特性，可诱导犬的ICP呈剂量依赖性升高并引发完全勃起。
