Werner B, de Heer K, Mitschke H
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977;88(3):223-30. doi: 10.1007/BF00305360.
The influence of cholecystectomy on the development of carcinoma of the colon is investigated. The experimental results show a significantly increased rate of carcinoma of the colon induced by subcutaneous injection of 1,2-Dimethylhydrazin (DMH) in the mouse after cholecystectomy. After 10 weekly injections of 15 mg/kg DMH, 70% of the animals with cholecystectomy developed carcinoma. Only 16% of the mice with similar treatment but without cholecystectomy had carcinoma. The cocarcinogenic effect of cholecystectomy is assumed to be due to the increased production of secondary bile salts by the colonic bacteria and the lacking of the resorptive function of the gallbladder for some carcinogenic substances passing through the liver. The background of this experimental studies are the clinical findings that 10% of patients with carcinoma of the large bowel had previous cholecystectomy.
研究了胆囊切除术对结肠癌发生发展的影响。实验结果表明，胆囊切除术后的小鼠经皮下注射1,2 - 二甲基肼（DMH）诱导的结肠癌发生率显著增加。每周注射15mg/kg DMH，共注射10周后，70%的胆囊切除动物发生了癌症。而接受类似处理但未行胆囊切除术的小鼠中，只有16%发生了癌症。胆囊切除术的促癌作用被认为是由于结肠细菌产生的次级胆汁盐增加，以及胆囊对某些经肝脏的致癌物质缺乏重吸收功能所致。该实验研究的背景是临床发现10%的大肠癌患者既往有胆囊切除术史。
