Flock S T, Jacques S L, Wilson B C, Star W M, van Gemert M J
Phillips Classic Biomedical Laser Research Laboratory, Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock 72205.
Lasers Surg Med. 1992;12(5):510-9. doi: 10.1002/lsm.1900120510.
Intralipid is an intravenous nutrient consisting of an emulsion of phospholipid micelles and water. Because Intralipid is turbid and has no strong absorption bands in the visible region of the electromagnetic spectrum, and is readily available and relatively inexpensive, it is often used as a tissue simulating phantom medium in light dosimetry experiments. In order to assist investigators requiring a controllable medium that over a finite range of wavelengths is optically equivalent to tissue, we have compiled previously published values of the optical interaction coefficients of Intralipid, most of which were measured at a wavelength of 633 nm. We have extended the measurements of the absorption and reduced scattering coefficients from 460 to 690 nm and the total attenuation coefficient from 500 to 890 nm. These measurements show that, for stock 10% Intralipid, the absorption coefficient varies from 0.015 to 0.001 cm-1 between 460 and 690 nm, the reduced scattering coefficient varies from 92 to 50 cm-1 between 460 and 690 nm, the total attenuation coefficient varies from 575 to 150 cm-1 between 500 and 890 nm, and the average cosine of scatter varies from 0.87 to 0.82 between 460 and 690 nm. With these data, we discuss the design of an optically tissue-equivalent phantom consisting of Intralipid and black India ink.
英脱利匹特是一种静脉营养剂，由磷脂微胶粒与水的乳剂组成。由于英脱利匹特呈浑浊状，且在电磁光谱的可见光区域没有强吸收带，并且容易获得且相对便宜，因此它常被用作光剂量学实验中的组织模拟体模介质。为了帮助需要一种在有限波长范围内光学性质与组织等效的可控介质的研究人员，我们汇编了先前发表的英脱利匹特光学相互作用系数的值，其中大部分是在波长633nm处测量的。我们将吸收系数和约化散射系数的测量范围扩展到了460至690nm，将总衰减系数的测量范围扩展到了500至890nm。这些测量结果表明，对于10%的原液英脱利匹特，在460至690nm之间，吸收系数从0.015变化到0.001cm⁻¹，约化散射系数从92变化到50cm⁻¹，在500至890nm之间，总衰减系数从575变化到150cm⁻¹，并且在460至690nm之间，散射的平均余弦值从0.87变化到0.82。利用这些数据，我们讨论了一种由英脱利匹特和黑色印度墨水组成的光学组织等效体模的设计。
