Cubeddu R, Pifferi A, Taroni P, Torricelli A, Valentini G
CEQSE-CNR, Milano, Italy.
Phys Med Biol. 1997 Oct;42(10):1971-9. doi: 10.1088/0031-9155/42/10/011.
A solid tissue phantom made of agar, Intralipid and black ink is described and characterized. The preparation procedure is fast and easily implemented with standard laboratory equipment. An instrumentation for time-resolved transmittance measurements was used to determine the optical properties of the phantom. The absorption and the reduced scattering coefficients are linear with the ink and Intralipid concentrations, respectively. A systematic decrease of the reduced scattering coefficient dependent on the agar content is observed, but can easily be managed. The phantom is highly homogeneous and shows good repeatability among different preparations. Moreover, agar inclusions can be easily embedded in either solid or liquid matrixes, and no artefacts are caused by the solid-solid or solid-liquid interfaces. This allows one to produce reliable and realistic inhomogeneous phantoms with known optical properties, particularly interesting for studies on optical imaging through turbid media.
描述并表征了一种由琼脂、脂质乳剂和黑色墨水制成的固体组织模型。制备过程快速，使用标准实验室设备即可轻松实现。使用用于时间分辨透射率测量的仪器来确定该模型的光学特性。吸收系数和约化散射系数分别与墨水和脂质乳剂浓度呈线性关系。观察到约化散射系数随琼脂含量的增加而系统性降低，但这很容易控制。该模型具有高度均匀性，不同制备之间具有良好的重复性。此外，琼脂内含物可以轻松嵌入固体或液体基质中，固-固或固-液界面不会产生伪影。这使得人们能够制作出具有已知光学特性的可靠且逼真的非均匀模型，对于通过混浊介质进行光学成像的研究尤为重要。
