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Defensins: microbicidal and cytotoxic peptides of mammalian host defense cells.

作者信息

Ganz T, Oren A, Lehrer R I

机构信息

Will Rogers Institute Pulmonary Research Laboratory, Department of Medicine, UCLA School of Medicine 90024-1736.

出版信息

Med Microbiol Immunol. 1992;181(2):99-105. doi: 10.1007/BF00189428.

DOI:10.1007/BF00189428
PMID:1406461
Abstract
摘要

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Defensins: microbicidal and cytotoxic peptides of mammalian host defense cells.
Med Microbiol Immunol. 1992;181(2):99-105. doi: 10.1007/BF00189428.
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Defensins: antimicrobial and cytotoxic peptides of mammalian cells.防御素：哺乳动物细胞的抗菌和细胞毒性肽。
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Microbicidal/cytotoxic proteins of neutrophils are deficient in two disorders: Chediak-Higashi syndrome and "specific" granule deficiency.中性粒细胞的杀菌/细胞毒性蛋白在两种疾病中存在缺陷：切-希二氏综合征和“特异性”颗粒缺乏症。
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Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens.巨噬细胞获取中性粒细胞颗粒以对抗细胞内病原体，发挥抗菌活性。
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Serum β-Defensin 2, A Novel Biomarker for the Diagnosis of Acute Infections.血清β-防御素2，一种用于诊断急性感染的新型生物标志物。
Diagnostics (Basel). 2023 May 28;13(11):1885. doi: 10.3390/diagnostics13111885.
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Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications.具有选择性抗肿瘤机制的抗菌肽：抗癌应用前景
Oncotarget. 2017 Jul 11;8(28):46635-46651. doi: 10.18632/oncotarget.16743.
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Characterization of Antimicrobial Peptides toward the Development of Novel Antibiotics.抗菌肽的特性及其在新型抗生素开发中的应用。

本文引用的文献

1
Increased content of microbicidal cationic peptides in rabbit alveolar macrophages elicited by complete Freund adjuvant.完全弗氏佐剂诱导兔肺泡巨噬细胞中杀菌阳离子肽含量增加。
Infect Immun. 1981 Sep;33(3):775-8. doi: 10.1128/iai.33.3.775-778.1981.
2
Primary structures of MCP-1 and MCP-2, natural peptide antibiotics of rabbit lung macrophages.兔肺巨噬细胞天然肽抗生素MCP - 1和MCP - 2的一级结构
J Biol Chem. 1983 Dec 10;258(23):14485-9.
3
Primary structures of three human neutrophil defensins.三种人类中性粒细胞防御素的一级结构。
Pharmaceuticals (Basel). 2013 Aug 21;6(8):1055-81. doi: 10.3390/ph6081055.
4
Rat recombinant β-defensin 22 is a heparin-binding protein with antimicrobial activity.鼠重组β-防御素 22 是一种具有抗菌活性的肝素结合蛋白。
Asian J Androl. 2011 Mar;13(2):305-11. doi: 10.1038/aja.2010.93. Epub 2010 Dec 13.
5
Fusobacterium nucleatum-associated beta-defensin inducer (FAD-I): identification, isolation, and functional evaluation.具核梭杆菌相关β防御素诱导物（FAD-I）：鉴定、分离和功能评估。
J Biol Chem. 2010 Nov 19;285(47):36523-31. doi: 10.1074/jbc.M110.133140. Epub 2010 Sep 16.
6
Immunosenescence and influenza vaccine efficacy.免疫衰老与流感疫苗效力
Curr Top Microbiol Immunol. 2009;333:413-29. doi: 10.1007/978-3-540-92165-3_20.
7
Selective reciprocity in antimicrobial activity versus cytotoxicity of hBD-2 and crotamine.人β-防御素2（hBD-2）和巴胺在抗菌活性与细胞毒性方面的选择性相互作用。
Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14972-7. doi: 10.1073/pnas.0904465106. Epub 2009 Aug 13.
8
The clinical value of neutrophil extracellular traps.中性粒细胞胞外诱捕网的临床价值。
Med Microbiol Immunol. 2009 Nov;198(4):211-9. doi: 10.1007/s00430-009-0121-x. Epub 2009 Aug 4.
9
Host defense peptides in wound healing.伤口愈合中的宿主防御肽
Mol Med. 2008 Jul-Aug;14(7-8):528-37. doi: 10.2119/2008-00002.Steinstraesser.
10
Role of YadA in resistance to killing of Yersinia enterocolitica by antimicrobial polypeptides of human granulocytes.YadA在小肠结肠炎耶尔森菌抵抗人粒细胞抗菌多肽杀伤作用中的作用。
Infect Immun. 1996 May;64(5):1653-8. doi: 10.1128/iai.64.5.1653-1658.1996.
J Clin Invest. 1985 Oct;76(4):1436-9. doi: 10.1172/JCI112121.
4
Newborn rabbit alveolar macrophages are deficient in two microbicidal cationic peptides, MCP-1 and MCP-2.新生兔肺泡巨噬细胞缺乏两种杀菌阳离子肽，即MCP-1和MCP-2。
Am Rev Respir Dis. 1985 Oct;132(4):901-4. doi: 10.1164/arrd.1985.132.4.901.
5
Primary structures of six antimicrobial peptides of rabbit peritoneal neutrophils.兔腹膜中性粒细胞六种抗菌肽的一级结构
J Biol Chem. 1985 Apr 25;260(8):4579-84.
6
In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes.人及兔粒细胞肽防御素介导的体外肿瘤细胞溶解作用
Blood. 1986 Dec;68(6):1407-10.
7
Two-dimensional NMR studies of the antimicrobial peptide NP-5.抗菌肽NP-5的二维核磁共振研究
Biochemistry. 1987 Jul 14;26(14):4389-97. doi: 10.1021/bi00388a030.
8
Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes.人类多形核白细胞对抗菌防御素的细胞外释放。
Infect Immun. 1987 Mar;55(3):568-71. doi: 10.1128/iai.55.3.568-571.1987.
9
Purification, primary structure, and antimicrobial activities of a guinea pig neutrophil defensin.豚鼠中性粒细胞防御素的纯化、一级结构及抗菌活性
Infect Immun. 1987 Sep;55(9):2281-6. doi: 10.1128/iai.55.9.2281-2286.1987.
10
Isolation and characterization of human defensin cDNA clones.人防御素cDNA克隆的分离与鉴定
Proc Natl Acad Sci U S A. 1988 Oct;85(19):7327-31. doi: 10.1073/pnas.85.19.7327.