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Production in mice of tolerance to the toxic manifestations of Candida albicans.使小鼠对白假丝酵母菌的毒性表现产生耐受性。
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小鼠对白念珠菌的获得性免疫

ACQUIRED IMMUNITY TO CANDIDIASIS IN MICE.

作者信息

HASENCLEVER H F, MITCHELL W O

出版信息

J Bacteriol. 1963 Sep;86(3):401-6. doi: 10.1128/jb.86.3.401-406.1963.

DOI:10.1128/jb.86.3.401-406.1963
PMID:14066415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC278449/
Abstract

Hasenclever, H. F. (National Institute of Allergy and Infectious Diseases, Bethesda, Md.) and William O. Mitchell. Acquired immunity to candidiasis in mice. J. Bacteriol. 86:401-406. 1963.-Some protection to chronic candidiasis in mice was produced by sublethal intraperitoneal infection with Candida albicans and by the injection in incomplete Freund's adjuvant of nonviable Coccidioides immitis spherule fragments. Other pathogenic or nonpathogenic fungi produced little or no protection. Salmonella enteritidis lipopolysaccharide, known to protect mice against the acute toxic manifestations of C. albicans, had no effect upon chronic candidiasis. A factor active in vitro against the growth of C. albicans was shown to be in the serum of resistant mice.

摘要

哈森克莱弗,H.F.(国立过敏与传染病研究所,马里兰州贝塞斯达)和威廉·O.米切尔。小鼠对白念珠菌病的获得性免疫。《细菌学杂志》86:401 - 406。1963年。——用白念珠菌进行亚致死性腹腔感染以及在不完全弗氏佐剂中注射灭活的粗球孢子菌球囊碎片,可使小鼠对慢性白念珠菌病产生一定程度的保护。其他致病性或非致病性真菌几乎没有或根本没有产生保护作用。已知能保护小鼠免受白念珠菌急性毒性表现影响的肠炎沙门氏菌脂多糖,对慢性白念珠菌病没有作用。已证明抗性小鼠血清中存在一种在体外对白念珠菌生长有活性的因子。