Gressens P, Kosofsky B E, Evrard P
Laboratoire de Neurologie du Développement, University of Louvain Medical School, Brussels, Belgium.
Neurosci Lett. 1992 Jun 8;140(1):113-6. doi: 10.1016/0304-3940(92)90694-3.
Exposure of fetuses to cocaine can induce behavioral disturbances and structural modifications of the CNS. Cocaine was injected into pregnant mice from the eighth day of gestation until term and the brains of their offspring were examined at the light and EM levels. Cocaine severely disturbs neocortical architecture, disrupting horizontal and vertical lamination, and inducing abnormal array of the axonal-dendritic bundles. Cocaine also alters several steps of gliogenesis. The severity of the malformations is variable, but evident in all exposed animals.
胎儿接触可卡因可诱发中枢神经系统的行为紊乱和结构改变。从妊娠第8天至足月，将可卡因注射到怀孕小鼠体内，并在光学和电子显微镜水平检查其后代的大脑。可卡因严重扰乱新皮质结构，破坏水平和垂直分层，并诱导轴突-树突束排列异常。可卡因还会改变神经胶质生成的几个步骤。畸形的严重程度各不相同，但在所有接触可卡因的动物中都很明显。
