Burzynski N J, Flynn M B, Faller N M, Ragsdale T L
Department of Diagnosis and General Dentistry, School of Dentistry, J. Graham Brown Cancer Center, University of Louisville, Ky.
Oral Surg Oral Med Oral Pathol. 1992 Sep;74(3):404-8. doi: 10.1016/0030-4220(92)90086-6.
Oral squamous cell carcinoma in patients 40 years of age and younger has been noted to be infrequent. The incidence is not as noticeable because the majority of oral cancers are diagnosed during the later decades of life. This study was undertaken to evaluate the incidence, site predilection, etiologic factors, and modes of treatment and to compare these results with available data on this topic. Of 1387 cases of oral and pharyngeal squamous cell carcinoma diagnosed from 1968 to 1989 at University Hospital and affiliated institutions, 28 occurred in patients under 40 years of age. When these lesions were staged according to the American Joint Committee for Cancer Staging, we found 6 stage I lesions, 3 stage II, 2 stage III, and 11 stage IV. Six lesions could not be staged from information available in the patient records. Present data corroborate the national average of 1% to 3% of cases of oral squamous cell carcinoma found within the 40 and under age group.
据观察，40岁及以下患者的口腔鳞状细胞癌并不常见。其发病率不太显著，因为大多数口腔癌是在生命的后几十年被诊断出来的。本研究旨在评估发病率、部位偏好、病因因素和治疗方式，并将这些结果与该主题的现有数据进行比较。在1968年至1989年期间，大学医院及附属机构诊断出1387例口腔和咽部鳞状细胞癌病例，其中28例发生在40岁以下的患者中。当根据美国癌症联合委员会的癌症分期标准对这些病变进行分期时，我们发现有6例为I期病变，3例为II期，2例为III期，11例为IV期。根据患者记录中的现有信息，有6例病变无法分期。目前的数据证实了40岁及以下年龄组中口腔鳞状细胞癌病例占全国平均水平的1%至3%。
