Tabah R J, Razack M S, Sako K
Rosewll Park Memorial Institute, Department of Head and Neck Surgery, Buffalo, New York 14263.
J Surg Oncol. 1988 May;38(1):22-5. doi: 10.1002/jso.2930380108.
In order to define the clinical behavior and characteristics of oral and oropharyngeal squamous cancer in nontobacco users, 40 surgically treated American Joint Commission (AJC) stage I and II tumors in 36 nontobacco-using patients were retrosepctively compared with 306 similarly staged and treated tumors in 286 tobacco-using patients. Significantly more nontobacco-associated tumors were found in females (P less than 0.005) whose mean age was significantly greater than that of tobacco users (P less than 0.001). Nontobacco users had proportionately more tumors of the buccal mucosa, oral tongue, and hard palate and fewer of the floor of mouth (P less than .025). There was no difference in the distribution of histologic grades between the two groups. The incidence of initial or subsequent nodal disease and the incidence of second upper aerodigestive tract cancers were similar. Despite similar rates of failure of initial treatment, the mean time to failure was significantly greater in nontobacco users (P less than 0.01). There was no difference in determinate 5-year survival between the two groups. Oral and oropharyngeal cancers in nontobacco users are no more aggressive than similar lesions in tobacco users.
为了明确非吸烟患者口腔及口咽鳞状细胞癌的临床行为和特征，对36例非吸烟患者中40例经手术治疗的美国癌症联合委员会（AJC）I期和II期肿瘤进行回顾性分析，并与286例吸烟患者中306例分期和治疗方式相似的肿瘤进行比较。结果发现，女性患者中非吸烟相关肿瘤显著更多（P<0.005），其平均年龄显著高于吸烟患者（P<0.001）。非吸烟患者中，颊黏膜、口腔舌部和硬腭部肿瘤比例更高，而口底肿瘤比例更低（P<0.025）。两组组织学分级分布无差异。两组患者初发或继发淋巴结疾病的发生率以及上呼吸消化道第二原发癌的发生率相似。尽管初始治疗失败率相似，但非吸烟患者的平均失败时间显著更长（P<0.01）。两组患者的5年确诊生存率无差异。非吸烟患者的口腔及口咽癌并不比吸烟患者的类似病变更具侵袭性。
