Cusumano R J, Persky M S
Department of Otolaryngology, New York University Medical Center, NY 10016.
Head Neck Surg. 1988 Mar-Apr;10(4):229-34. doi: 10.1002/j.1930-2398.1988.tb00004.x.
Studies of squamous cell carcinoma of the oral cavity and oropharynx in young adults differ as to whether younger patients resemble the general population of head and neck cancer patients. A retrospective study was performed on 23 patients (40 years old or younger) with oral and oropharyngeal carcinoma at New York University Medical Center between 1961 and 1984. Patients with oropharyngeal cancer resembled the general population of head and neck cancer patients. In contrast, oral cavity carcinoma occurred more frequently in women under the age of 35 and lacked the usual etiologic factors of tobacco and alcohol abuse. Survival correlated best with the TNM stage of disease at initial presentation. Patients with Stage I and II lesions had an excellent response to surgical treatment alone and a high 5-year survival rate. Patients with advanced Stage III and IV disease had a poor survival rate with single modality treatment. We recommend surgery and radiotherapy in patients with advanced disease.
关于年轻成年人的口腔和口咽鳞状细胞癌患者是否与头颈癌患者的总体人群相似，相关研究存在差异。1961年至1984年间，纽约大学医学中心对23例年龄在40岁及以下的口腔和口咽癌患者进行了一项回顾性研究。口咽癌患者与头颈癌患者的总体人群相似。相比之下，口腔癌在35岁以下女性中更为常见，且缺乏常见的烟草和酒精滥用等病因。生存率与初次就诊时疾病的TNM分期相关性最佳。I期和II期病变的患者对单纯手术治疗反应良好，5年生存率较高。III期和IV期晚期疾病的患者采用单一治疗方式时生存率较低。我们建议对晚期疾病患者采用手术和放疗。
