Jansen D F, Nedeljkovic S, Feskens E J, Ostojic M C, Grujic M Z, Bloemberg B P, Kromhout D
Department of Chronic Diseases and Environmental Epidemiology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
Arterioscler Thromb Vasc Biol. 1995 Nov;15(11):1793-7.
The associations between serum total and HDL cholesterol and three lifestyle factors--consumption of Turkish coffee, consumption of alcohol, and cigarette smoking--were examined in two Serbian cohorts of the Seven Countries Study. In 1988 and 1989, 319 men from Zrenjanin and Belgrade, 65 to 84 years old and free of myocardial infraction, participated. The men from Zrenjanin were originally working in a large cooperative, and the men from Belgrade were faculty members of the university. HDL cholesterol, alcohol consumption, and cigarette smoking were significantly higher in Zrenjanin than in Belgrade. Serum total cholesterol levels and coffee consumption were not different. ANCOVA showed that serum total cholesterol levels were 8.2% higher (P < .05) in men consuming two small cups of coffee per day compared with abstainers, and this was also seen after adjustment for cigarette smoking, age, body mass index, cohort, and alcohol consumption. In men consuming one or more alcoholic drinks per day (more than 10 g/d alcohol), HDL cholesterol levels were increased by 0.19 mmol/L (15.4%) compared with men consuming no alcohol (P < .001). This association was stronger in the Zrenjanin cohort than in the Belgrade cohort (P < .05). Smoking was not associated with total cholesterol or with HDL cholesterol levels. In Serbian men, boiled Turkish coffee and alcohol consumption are independently associated with serum total and HDL cholesterol levels, respectively.
在七国研究的两个塞尔维亚队列中，研究了血清总胆固醇和高密度脂蛋白胆固醇与三种生活方式因素——饮用土耳其咖啡、饮酒和吸烟之间的关联。1988年和1989年，来自兹雷尼亚宁和贝尔格莱德的319名65至84岁且无心肌梗死的男性参与了研究。来自兹雷尼亚宁的男性最初在一家大型合作社工作，来自贝尔格莱德的男性是大学教员。兹雷尼亚宁的高密度脂蛋白胆固醇、饮酒量和吸烟率显著高于贝尔格莱德。血清总胆固醇水平和咖啡饮用量没有差异。协方差分析显示，每天饮用两杯小杯咖啡的男性血清总胆固醇水平比不饮用者高8.2%（P < .05），在调整吸烟、年龄、体重指数、队列和饮酒量后也观察到了这一结果。每天饮用一种或多种酒精饮料（酒精摄入量超过10克/天）的男性，其高密度脂蛋白胆固醇水平比不饮酒的男性升高了0.19毫摩尔/升（15.4%）（P < .001）。这种关联在兹雷尼亚宁队列中比在贝尔格莱德队列中更强（P < .05）。吸烟与总胆固醇或高密度脂蛋白胆固醇水平无关。在塞尔维亚男性中，煮制的土耳其咖啡和饮酒分别与血清总胆固醇和高密度脂蛋白胆固醇水平独立相关。
