饮用绿茶对心血管疾病和肝脏疾病影响的横断面研究。
Cross sectional study of effects of drinking green tea on cardiovascular and liver diseases.
作者信息
Imai K, Nakachi K
机构信息
Department of Epidemiology, Saitama Cancer Center Research Institute, Japan.
出版信息
BMJ. 1995 Mar 18;310(6981):693-6. doi: 10.1136/bmj.310.6981.693.
OBJECTIVE
To investigate the association between consumption of green tea and various serum markers in a Japanese population, with special reference to preventive effects of green tea against cardiovascular disease and disorders of the liver.
DESIGN
Cross sectional study.
SETTING
Yoshimi, Japan.
SUBJECTS
1371 men aged over 40 years resident in Yoshimi and surveyed on their living habits including daily consumption of green tea. Their peripheral blood samples were subjected to several biochemical assays.
RESULTS
Increased consumption of green tea was associated with decreased serum concentrations of total cholesterol (P for trend < 0.001) and triglyceride (P for trend = 0.02) and an increased proportion of high density lipoprotein cholesterol together with a decreased proportion of low and very low lipoprotein cholesterols (P for trend = 0.02), which resulted in a decreased atherogenic index (P for trend = 0.02). Moreover, increased consumption of green tea, especially more than 10 cups a day, was related to decreased concentrations of hepatological markers in serum, aspartate aminotransferase (P for trend = 0.06), alanine transferase (P for trend = 0.07), and ferritin (P for trend = 0.02).
CONCLUSION
The inverse association between consumption of green tea and various serum markers shows that green tea may act protectively against cardiovascular disease and disorders of the liver.
目的
调查日本人群中绿茶摄入量与各种血清标志物之间的关联，特别关注绿茶对心血管疾病和肝脏疾病的预防作用。
设计
横断面研究。
地点
日本吉见。
研究对象
居住在吉见的1371名40岁以上男性，对他们的生活习惯进行了调查，包括绿茶的每日摄入量。采集他们的外周血样本进行多项生化检测。
结果
绿茶摄入量增加与总胆固醇血清浓度降低（趋势P<0.001）、甘油三酯降低（趋势P=0.02）以及高密度脂蛋白胆固醇比例增加、低密度和极低密度脂蛋白胆固醇比例降低相关（趋势P=0.02），这导致动脉粥样硬化指数降低（趋势P=0.02）。此外，绿茶摄入量增加，尤其是每天超过10杯，与血清中肝脏标志物天冬氨酸转氨酶（趋势P=0.06）、丙氨酸转氨酶（趋势P=0.07）和铁蛋白（趋势P=0.02）浓度降低有关。
结论
绿茶摄入量与各种血清标志物之间的负相关表明，绿茶可能对心血管疾病和肝脏疾病具有保护作用。
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