Biegon A, Greuner N
Lawrence Berkeley Laboratory, University of California, Berkeley 94720.
Psychopharmacology (Berl). 1992;108(1-2):210-2. doi: 10.1007/BF02245309.
Serotonin receptors of the 5HT2 type were labeled on platelet membranes using tritiated ketanserin. Blood was collected from the umbilical cord of newborns and venous samples were collected from 6-year-old children as well as junior-high and high school students (ages 13 through 18) to determine age-related changes in receptor binding. Among the ages sampled, the highest levels of 5HT2 receptor binding were found in 6-year-olds. A sharp decline in receptor binding occurred during adolescence, with levels reduced by half between ages 13 and 17. This pattern is similar to the one we have observed in brain 5HT2 receptors postmortem. There were no significant sex differences in 5HT2 receptors on platelets in newborn and young children. A trend towards higher binding in girls appears around the onset of menstruation in teenage girls (age 14 and up). These results demonstrate that platelet 5HT2 receptors can serve as a model for age dependent changes in 5HT2 receptors in the brain.
使用氚标记的酮色林标记血小板膜上的5HT2型血清素受体。采集新生儿脐带血，以及6岁儿童、初中生和高中生（13至18岁）的静脉血样本，以确定受体结合的年龄相关变化。在采样的年龄组中，6岁儿童的5HT2受体结合水平最高。青春期受体结合急剧下降，13至17岁之间的水平减半。这种模式与我们在死后大脑5HT2受体中观察到的模式相似。新生儿和幼儿血小板上的5HT2受体没有显著的性别差异。在十几岁女孩月经初潮（14岁及以上）时，女孩的结合水平有升高的趋势。这些结果表明，血小板5HT2受体可作为大脑中5HT2受体年龄依赖性变化的模型。
