Blumensohn R, Ratzoni G, Weizman A, Israeli M, Greuner N, Apter A, Tyano S, Biegon A
New Ziona Psychiatric Hospital, Israel.
Psychopharmacology (Berl). 1995 Apr;118(3):354-6. doi: 10.1007/BF02245966.
The possible involvement of serotonin receptors of the 5HT2 type in aggressive behavior was studied in juvenile delinquents. A group of 28 delinquent adolescents (13-18 years old) who had committed violent crimes was compared with a group of age matched controls. Subjects were drug and medication free during the study. 5HT2 receptors were labeled on platelet membranes using tritiated ketanserin. Receptor binding in the delinquent adolescents was significantly lower than in age matched controls. Mean +/- SD of 76 controls was 32.3 +/- 14.2 fm/mg, compared to 16.6 +/- 8.2 fm/mg in 28 delinquents (P < 0.002, Student's t-test). These results support a role for serotonin in general and 5HT2 receptors in particular in human aggressive behavior.
对青少年犯罪者中5HT2型血清素受体在攻击性行为中可能的作用进行了研究。将一组28名实施暴力犯罪的青少年犯罪者（13 - 18岁）与一组年龄匹配的对照组进行比较。研究期间，受试者未使用药物和其他治疗手段。使用氚标记的酮色林标记血小板膜上的5HT2受体。青少年犯罪者的受体结合显著低于年龄匹配的对照组。76名对照组的平均值±标准差为32.3±14.2 fm/mg，而28名犯罪者为16.6±8.2 fm/mg（P < 0.002，学生t检验）。这些结果支持了血清素总体上，尤其是5HT2受体在人类攻击性行为中起作用的观点。
