Vyskocil A, Smejkalova J, Tejral J, Emminger S, Vincentova M, Ettlerova E, Lauwerys R, Bernard A
Charles University, Hradec Kralové, Czechoslovakia.
Scand J Work Environ Health. 1992 Aug;18(4):252-6. doi: 10.5271/sjweh.1581.
Biochemical markers of kidney damage were examined in 52 male stainless steel welders (manual metal arc welding) exposed to chromium and nickel. No difference was found in the mean urinary excretion of total proteins, albumin, protein 1, transferrin, retinol-binding protein, lactate dehydrogenase, lysozyme, or beta-N-acetylglucosaminidase in a comparison with matched referents. Beta 2-microglobulin was slightly increased in those welders with a urinary chromium concentration of greater than 64.5 nmol.mmol-1 creatinine. The prevalences of abnormal values did not differ from those observed in the reference group. No correlation was found between the concentrations of chromium or nickel in urine and that of proteins or enzymes. No consistent or clinically significant renal impairment was revealed among the stainless steel welders exposed to a chromium air concentration slightly above the current threshold limit value of the American Conference of Governmental Industrial Hygienists for water-soluble hexavalent chromium compounds (50 micrograms.m-3).
对52名接触铬和镍的男性不锈钢焊工（手工电弧焊）进行了肾损伤生化标志物检查。与匹配的对照组相比，总蛋白、白蛋白、蛋白1、转铁蛋白、视黄醇结合蛋白、乳酸脱氢酶、溶菌酶或β-N-乙酰氨基葡萄糖苷酶的平均尿排泄量未发现差异。尿铬浓度大于64.5 nmol·mmol⁻¹肌酐的焊工中，β2-微球蛋白略有升高。异常值的患病率与参考组观察到的患病率没有差异。尿中铬或镍的浓度与蛋白质或酶的浓度之间未发现相关性。在接触的空气中铬浓度略高于美国政府工业卫生学家会议目前对水溶性六价铬化合物设定的阈限值（50微克·m⁻³）的不锈钢焊工中，未发现一致的或具有临床意义的肾功能损害。
