SHOPE R E
J Exp Med. 1964 Mar 1;119(3):357-68. doi: 10.1084/jem.119.3.357.
An acute frequently rapidly fatal respiratory illness occurring as an epidemic disease in Argentine swine has been shown to have a bacterium of the genus Hemophilus as its causative agent. This organism, for which the name Hemophilus pleuropneumoniae is suggested, causes a singular, fulminating pleuropneumonia in experimental swine. The very marked effectiveness of H. pleuropneumoniae as a respiratory pathogen contrasts strikingly with the relatively mild pathogenicity of the well known swine Hemophilus, H. influenzae suis, which, in concert with a virus, causes a less highly fatal respiratory ailment, swine influenza. Porcine contagious pleuropneumonia (PCP) is contagious under experimental conditions. In the pathogenesis of the disease, histopathological studies of early cases suggest that the lymphatics of the lung and pleura may be primarily involved and that the pneumonia and pleuritis then proceed from these initial sites of reaction.
在阿根廷猪群中作为一种流行病出现的一种急性、通常迅速致命的呼吸道疾病，已被证明其病原体是嗜血杆菌属的一种细菌。这种微生物，建议命名为胸膜肺炎嗜血杆菌，在实验猪中引起一种独特的、暴发性的胸膜肺炎。胸膜肺炎嗜血杆菌作为呼吸道病原体的显著有效性，与著名的猪嗜血杆菌——猪流感嗜血杆菌相对温和的致病性形成鲜明对比，猪流感嗜血杆菌与一种病毒共同作用，引起一种致死率较低的呼吸道疾病——猪流感。猪传染性胸膜肺炎（PCP）在实验条件下具有传染性。在该疾病的发病机制中，早期病例的组织病理学研究表明，肺和胸膜的淋巴管可能首先受累，然后肺炎和胸膜炎从这些初始反应部位发展而来。
