Perrella O, Soscia M, Iaccarino C, Carrieri P B
III Department D, Cotugno Hospital for Infectious Diseases, Napoli, Italy.
J Biol Regul Homeost Agents. 1992 Apr-Jun;6(2):53-6.
A subset of peripheral T cells, whose physiological function is little known, expresses a distinct CD3-associated receptor composed of gamma and delta chains. We used two monoclonal antibodies to characterize the TcR gamma/delta lymphocytes (TcR delta 1+) and their fraction (TcS delta 1+) in peripheral blood and cerebrospinal fluid of patients affected by AIDS dementia complex (ADC). Thirty patients with ADC and a control group of twenty individuals with other non-inflammatory neurological diseases (OND) were recruited. Our results demonstrate that the TcR gamma/delta cells were also present in cerebrospinal fluid of ADC patients, but we did not find any statistical difference between the two groups.
外周血T细胞的一个亚群表达由γ和δ链组成的独特的CD3相关受体，其生理功能鲜为人知。我们使用两种单克隆抗体对艾滋病痴呆综合征（ADC）患者外周血和脑脊液中的TcRγ/δ淋巴细胞（TcRδ1+）及其亚群（TcSδ1+）进行了表征。招募了30例ADC患者和20例患有其他非炎性神经疾病（OND）的个体作为对照组。我们的结果表明，ADC患者的脑脊液中也存在TcRγ/δ细胞，但两组之间未发现任何统计学差异。
