孕中期和孕晚期胎儿的循环淋巴细胞亚群：与新生儿及成人的比较。

Circulating lymphocyte subsets in second- and third-trimester fetuses: comparison with newborns and adults.

作者信息

Berry S M, Fine N, Bichalski J A, Cotton D B, Dombrowski M P, Kaplan J

机构信息

Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI.

出版信息

Am J Obstet Gynecol. 1992 Oct;167(4 Pt 1):895-900. doi: 10.1016/s0002-9378(12)80008-1.

DOI:10.1016/s0002-9378(12)80008-1

PMID:1415422

Abstract

OBJECTIVES

Our objective was to compare the relative sizes of circulating lymphocyte subsets in fetuses, newborns, and adults.

STUDY DESIGN

Two-color flow cytometric analysis of lymphocyte cell surface markers was performed on blood from 64 fetuses, 22 newborns, and 67 normal adults.

RESULTS

All three groups had similar percentages of CD3+ total T cells, CD4+ helper T cells, CD8+ cytotoxic/suppressor T cells, and CD20+ B cells. Compared with adults, fetuses and newborns had markedly reduced percentages of CD57+ natural killer T cells and consistently increased percentages of CD5+CD20+ B cells. Most fetal and cord T and B lymphocytes expressed the activation marker CD38.

CONCLUSIONS

Similarities and age-dependent differences exist among fetal, newborn, and adult circulating lymphocyte subsets. Lymphocyte marker analysis may prove useful in the detection of fetal infection and other complications of gestation.

摘要

目的

我们的目的是比较胎儿、新生儿和成人循环淋巴细胞亚群的相对大小。

研究设计

对64例胎儿、22例新生儿和67例正常成人的血液进行淋巴细胞细胞表面标志物的双色流式细胞术分析。

结果

所有三组的CD3 + 总T细胞、CD4 + 辅助性T细胞、CD8 + 细胞毒性/抑制性T细胞和CD20 + B细胞百分比相似。与成人相比，胎儿和新生儿的CD57 + 自然杀伤性T细胞百分比明显降低，而CD5 + CD20 + B细胞百分比持续升高。大多数胎儿和脐带T及B淋巴细胞表达活化标志物CD38。