Sano T, Kawachi T, Matsukura N, Sasajima K, Sugimura T
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977 May 20;89(1):61-8. doi: 10.1007/BF02571690.
The carcinogenicity of a food additive, 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide (trade name, AF-2), was studied. A diet containing AF-2 at a rate of 0.25% was administered to male golden hamsters and male ddY mice. The hamsters developed squamous cell carcinomas in the forestomach after the 49th day from the start of administration. In mice fed a AF-2 diet for 308 days, squamous cell carcinoma was observed in the forestomach after the 381th day from the start of the experiment; in some cases the carcinoma metastasized to the lung and liver.
对一种食品添加剂2-(2-呋喃基)-3-(5-硝基-2-呋喃基)丙烯酰胺（商品名，AF-2）的致癌性进行了研究。以0.25%的比例含有AF-2的饲料被喂给雄性金黄仓鼠和雄性ddY小鼠。从给药开始第49天后，仓鼠在前胃出现了鳞状细胞癌。在喂食含AF-2饲料308天的小鼠中，从实验开始第381天后在前胃观察到鳞状细胞癌；在某些情况下，癌转移到了肺和肝。
