PARETSKY D, DOWNS C M, SALMON C W
J Bacteriol. 1964 Jul;88(1):137-42. doi: 10.1128/jb.88.1.137-142.1964.
Paretsky, D. (University of Kansas, Lawrence), C. M. Downs, and C. W. Salmon. Some biochemical changes in the guinea pig during infection with Coxiella burnetii. J. Bacteriol. 88:137-142. 1964.-Guinea pigs infected with Coxiella burnetii, the rickettsial agent of Q fever, were studied for 11 days postinfection. Maximal changes in liver lipids, liver phosphorylase, and uridine diphosphate glucose (UDPG)-glycogen glucosyl-transferase activities occurred 3 to 4 days post-infection. In this period, total liver lipids increased from 1.26 to 5.46 mg/mg of N, with the largest increment in the glyceride fraction. Liver glycogen virtually disappeared by the second day, with no chemically detectable restoration until the eleventh day. A pattern of altered phosphorylase and UDPG-glycogen transglucosylase activities was observed, with maximal phosphorylase and minimal glucosyltransferase activities at the third and fourth days. Histochemical observations confirmed chemical analyses for lipids and glycogen.
帕雷茨基，D.（堪萨斯大学，劳伦斯），C.M.唐斯，以及C.W.萨蒙。豚鼠感染伯纳特立克次体期间的一些生化变化。《细菌学杂志》88:137 - 142。1964年。——对感染Q热立克次体病原体伯纳特立克次体的豚鼠在感染后11天进行了研究。肝脏脂质、肝脏磷酸化酶以及尿苷二磷酸葡萄糖（UDPG）-糖原葡糖基转移酶活性的最大变化发生在感染后3至4天。在此期间，肝脏总脂质从1.26毫克/毫克氮增加到5.46毫克/毫克氮，甘油酯部分增加最多。肝脏糖原在第二天几乎消失，直到第十一天才出现化学可检测到的恢复。观察到磷酸化酶和UDPG-糖原转葡糖基酶活性的一种变化模式，在第三天和第四天磷酸化酶活性最高，葡糖基转移酶活性最低。组织化学观察证实了脂质和糖原的化学分析结果。
