Q热期间肝脏糖原、蛋白质和核糖核酸合成的变化以及皮质醇的一些作用。
Changes in hepatic glycogen, protein, and ribonucleic acid synthesis, and some effects of cortisol, during Q fever.
作者信息
Stueckemann J, Paretsky D
出版信息
J Bacteriol. 1971 Jun;106(3):920-4. doi: 10.1128/jb.106.3.920-924.1971.
Abstract
Liver glycogen is depleted in guinea pigs infected with Coxiella burneti. Syntheses of the glycogen precursors uridine triphosphate and uridine diphosphate glucose are unaffected during Q fever, but glycogen synthetase activity is inhibited. Exogenous cortisol relieves this inhibition in infected animals. Orotate and amino acids are more rapidly incorporated into ribonucleic acid and protein during infection. It is proposed that the biochemical defect in the synthesis of glycogen lies in the inactivation of glycogen synthetase.
摘要
感染伯氏考克斯体的豚鼠肝脏糖原会被耗尽。在Q热期间，糖原前体三磷酸尿苷和二磷酸尿苷葡萄糖的合成未受影响，但糖原合成酶活性受到抑制。外源性皮质醇可缓解感染动物的这种抑制作用。在感染期间，乳清酸和氨基酸更快地掺入核糖核酸和蛋白质中。有人提出，糖原合成中的生化缺陷在于糖原合成酶的失活。
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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SOME BIOCHEMICAL CHANGES IN THE GUINEA PIG DURING INFECTION WITH COXIELLA BURNETII.豚鼠感染伯氏考克斯体期间的一些生化变化。
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