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1
Changes in hepatic glycogen, protein, and ribonucleic acid synthesis, and some effects of cortisol, during Q fever.Q热期间肝脏糖原、蛋白质和核糖核酸合成的变化以及皮质醇的一些作用。
J Bacteriol. 1971 Jun;106(3):920-4. doi: 10.1128/jb.106.3.920-924.1971.
2
Chemical and biochemical changes in subcellular fractions of guinea pig liver during infection with Coxiella burneti.豚鼠肝脏在感染伯纳特柯克斯体期间亚细胞组分中的化学和生化变化。
J Bacteriol. 1970 May;102(2):334-40. doi: 10.1128/jb.102.2.334-340.1970.
3
Ribonucleic acid and protein synthesis in guinea pig liver during Q fever.Q热期间豚鼠肝脏中的核糖核酸与蛋白质合成
Infect Immun. 1973 May;7(5):718-24. doi: 10.1128/iai.7.5.718-724.1973.
4
Some physiological and biochemical effects of a Coxiella burneti lipopolysaccharide preparation on guinea pigs.伯纳特柯克斯体脂多糖制剂对豚鼠的一些生理生化影响。
Infect Immun. 1974 May;9(5):939-45. doi: 10.1128/iai.9.5.939-945.1974.
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SOME BIOCHEMICAL CHANGES IN THE GUINEA PIG DURING INFECTION WITH COXIELLA BURNETII.豚鼠感染伯氏考克斯体期间的一些生化变化。
J Bacteriol. 1964 Jul;88(1):137-42. doi: 10.1128/jb.88.1.137-142.1964.
6
Studies on some aspects of glucose metabolism in guinea pigs infected with Coxiella burnetii.感染伯氏考克斯体的豚鼠葡萄糖代谢某些方面的研究。
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7
Divergent effects of actinomycin d on cortisol and on glucose stimulation of glycogenesis in mouse liver.放线菌素D对小鼠肝脏皮质醇及糖原生成的葡萄糖刺激作用的不同影响。
Biochem J. 1967 Jan;102(1):103-9. doi: 10.1042/bj1020103.
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Inhibitory effects of cortisol and antibiotics on substrate entry and ribonucleic acid synthesis in rat thymocytes in vitro.皮质醇和抗生素对大鼠胸腺细胞体外底物摄取及核糖核酸合成的抑制作用。
J Biol Chem. 1970 May 25;245(10):2556-63.
9
Biochemistry of rickettsiae and their infected hosts, with special reference to Coxiella burneti.立克次氏体及其感染宿主的生物化学，特别提及伯氏考克斯氏体。
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10
Physiology of rickettsiae. VII. Amino acid incorporation by Coxiella burnetii and by infected hosts.立克次氏体生理学。VII. 伯氏考克斯氏体及受感染宿主对氨基酸的摄取
J Bacteriol. 1967 May;93(5):1479-83. doi: 10.1128/jb.93.5.1479-1483.1967.

引用本文的文献

1
Q fever and Coxiella burnetii: a model for host-parasite interactions.Q热与贝纳柯克斯体：宿主-寄生虫相互作用的一个模型
Microbiol Rev. 1983 Jun;47(2):127-49. doi: 10.1128/mr.47.2.127-149.1983.
2
Phosphorylation-dephosphorylation of nuclear proteins during infection (Q fever).感染（Q热）期间核蛋白的磷酸化-去磷酸化
Infect Immun. 1984 Jan;43(1):14-20. doi: 10.1128/iai.43.1.14-20.1984.
3
Ribonucleic acid and protein synthesis in guinea pig liver during Q fever.Q热期间豚鼠肝脏中的核糖核酸与蛋白质合成
Infect Immun. 1973 May;7(5):718-24. doi: 10.1128/iai.7.5.718-724.1973.
4
Some physiological and biochemical effects of a Coxiella burneti lipopolysaccharide preparation on guinea pigs.伯纳特柯克斯体脂多糖制剂对豚鼠的一些生理生化影响。
Infect Immun. 1974 May;9(5):939-45. doi: 10.1128/iai.9.5.939-945.1974.
5
Ribosomal protein phosphorylation induced during Q fever or by lipopolysaccharide: in vitro translation is stimulated by infected liver ribosomes.Q热或脂多糖诱导的核糖体蛋白磷酸化：体外翻译受感染肝脏核糖体的刺激。
Infect Immun. 1985 Jun;48(3):690-6. doi: 10.1128/iai.48.3.690-696.1985.
6
Endotoxicosis induced by Coxiella burnetii lipopolysaccharide stimulates a ribosomal protein S6 kinase: some properties of the partially purified enzyme.伯氏考克斯氏体脂多糖诱导的内毒素血症刺激核糖体蛋白S6激酶：部分纯化酶的一些特性。
Infect Immun. 1989 Dec;57(12):3683-8. doi: 10.1128/iai.57.12.3683-3688.1989.

本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
STUDY OF THE ANTIGENIC STRUCTURE OF COXIELLA BURNETI. 3. PYROGENIC EFFECT OF PHASE I ANTIGEN IN EXPERIMENTAL GUINEA PIGS.伯纳特立克次体抗原结构的研究。3. 实验性豚鼠中Ⅰ相抗原的致热作用。
Acta Virol. 1965 Mar;9:180-5.
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STUDIES ON THE INDUCTION AND REPRESSION OF ENZYMES IN RAT LIVER. I. INDUCTION OF THREONINE DEHYDRASE AND ORNITHINE-DELTA-TRANSAMINASE BY ORAL INTUBATION OF CASEIN HYDROLYSATE.大鼠肝脏中酶的诱导与阻遏研究。I. 通过口服酪蛋白水解物诱导苏氨酸脱氢酶和鸟氨酸-δ-转氨酶
J Biol Chem. 1964 Jun;239:1783-8.
4
SOME BIOCHEMICAL CHANGES IN THE GUINEA PIG DURING INFECTION WITH COXIELLA BURNETII.豚鼠感染伯氏考克斯体期间的一些生化变化。
J Bacteriol. 1964 Jul;88(1):137-42. doi: 10.1128/jb.88.1.137-142.1964.
5
GLYCOGEN SYNTHETASE: ITS RESPONSE TO CORTISOL.糖原合成酶：其对皮质醇的反应。
Science. 1964 Feb 21;143(3608):816-7. doi: 10.1126/science.143.3608.816.
6
Study of glucose tolerance and synthesis of hepatic glycogen from glucose and glycine-1-C-14 in tuberculous guinea pigs.结核性豚鼠的葡萄糖耐量及由葡萄糖和甘氨酸-1-C-14合成肝糖原的研究。
Arch Biochem Biophys. 1963 May;101:229-33. doi: 10.1016/s0003-9861(63)80007-7.
7
Some factors influencing protein synthetic activity in a cell-free mammalian system.一些影响无细胞哺乳动物系统中蛋白质合成活性的因素。
Cold Spring Harb Symp Quant Biol. 1961;26:153-7. doi: 10.1101/sqb.1961.026.01.019.
8
Biosynthesis of glycogen from uridine diphosphate glucose.由尿苷二磷酸葡萄糖合成糖原。
Arch Biochem Biophys. 1959 Apr;81(2):508-20. doi: 10.1016/0003-9861(59)90232-2.
9
Glycogen studies on white rats infected with Plasmodium berghei.对感染伯氏疟原虫的白鼠进行糖原研究。
Exp Parasitol. 1954 May;3(3):259-66. doi: 10.1016/0014-4894(54)90025-9.
10
Uridine nucleotide compounds of liver.肝脏的尿苷核苷酸化合物
Biochim Biophys Acta. 1954 Mar;13(3):386-400. doi: 10.1016/0006-3002(54)90346-7.

Q热期间肝脏糖原、蛋白质和核糖核酸合成的变化以及皮质醇的一些作用。

Changes in hepatic glycogen, protein, and ribonucleic acid synthesis, and some effects of cortisol, during Q fever.

作者信息

Stueckemann J, Paretsky D

出版信息

J Bacteriol. 1971 Jun;106(3):920-4. doi: 10.1128/jb.106.3.920-924.1971.

DOI:10.1128/jb.106.3.920-924.1971
PMID:5557597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC248726/
Abstract

Liver glycogen is depleted in guinea pigs infected with Coxiella burneti. Syntheses of the glycogen precursors uridine triphosphate and uridine diphosphate glucose are unaffected during Q fever, but glycogen synthetase activity is inhibited. Exogenous cortisol relieves this inhibition in infected animals. Orotate and amino acids are more rapidly incorporated into ribonucleic acid and protein during infection. It is proposed that the biochemical defect in the synthesis of glycogen lies in the inactivation of glycogen synthetase.

摘要

感染伯氏考克斯体的豚鼠肝脏糖原会被耗尽。在Q热期间，糖原前体三磷酸尿苷和二磷酸尿苷葡萄糖的合成未受影响，但糖原合成酶活性受到抑制。外源性皮质醇可缓解感染动物的这种抑制作用。在感染期间，乳清酸和氨基酸更快地掺入核糖核酸和蛋白质中。有人提出，糖原合成中的生化缺陷在于糖原合成酶的失活。