KASUYA M
J Bacteriol. 1964 Aug;88(2):322-8. doi: 10.1128/jb.88.2.322-328.1964.
Kasuya, Morimasa (Nagoya University School of Medicine, Nagoya, Japan). Transfer of drug resistance between enteric bacteria induced in the mouse intestine. J. Bacteriol. 88:322-328. 1964.-Transfer of multiple drug resistance in the intestines of germ-free and conventional mice was studied with strains of Shigella, Escherichia, and Klebsiella. The transfer experiment was carried out under antibiotic-free conditions to eliminate the production of drug-resistant bacteria by antibiotics. All resistance factors (chloramphenicol, streptomycin, tetracycline, and sulfathiazole) were transferred with ease in the intestinal tracts of mice, when donors and recipients multiplied freely, and acquired resistance was further transferred to other sensitive enteric bacteria in the intestinal tract. Bacteria to which resistance factors were transferred showed, in most of the experiments, exactly the same level and pattern of resistance as the donors. Based on the above, a hypothesis that the same process may possibly occur in the human intestine is presented.
粕谷盛正（日本名古屋大学医学部，名古屋）。小鼠肠道中肠道细菌间耐药性的转移。《细菌学杂志》88:322 - 328。1964年。——利用志贺氏菌、大肠杆菌和克雷伯氏菌菌株，研究了无菌小鼠和普通小鼠肠道中多重耐药性的转移。转移实验在无抗生素条件下进行，以消除抗生素对耐药菌产生的影响。当供体菌和受体菌自由繁殖时，所有耐药因子（氯霉素、链霉素、四环素和磺胺噻唑）都能在小鼠肠道中轻易转移，获得的耐药性还能进一步转移给肠道中其他敏感的肠道细菌。在大多数实验中，获得耐药因子的细菌表现出与供体菌完全相同的耐药水平和模式。基于上述情况，提出了一个假说，即相同的过程可能在人类肠道中发生。
