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1
The relation between B-cell stimulation and delayed hypersensitivity. The effect of cyclophosphamide pretreatment on antibody production.B细胞刺激与迟发型超敏反应之间的关系。环磷酰胺预处理对抗体产生的影响。
Immunology. 1977 Jun;32(6):885-91.
2
The relation of immune depression and B-cell stimulation during the development of delayed hypersensitivity to soluble antigens.对可溶性抗原迟发型超敏反应发生过程中免疫抑制与B细胞刺激的关系。
Immunology. 1977 Feb;32(2):265-72.
3
Suppression of delayed hypersensitivity to tuberculin by antigenic competition. A positive immunoregulatory mechanism sensitive to cyclophosphamide.抗原竞争对结核菌素迟发型超敏反应的抑制。一种对环磷酰胺敏感的阳性免疫调节机制。
Immunology. 1981 Apr;42(4):549-59.
4
The relation between the cell-mediated immunological response and the induction of circulating antibodies to collagen in guinea-pigs.豚鼠体内细胞介导的免疫反应与循环抗胶原蛋白抗体诱导之间的关系。
Immunology. 1976 Jul;31(1):95-100.
5
The effect of cyclophosphamide pretreatment on B-cell stimulation: dissociation of action on homocytotropic antibody and other B-cell functions.环磷酰胺预处理对B细胞刺激的影响：对亲同种细胞抗体及其他B细胞功能作用的解离
Immunology. 1978 Jan;34(1):115-21.
6
Specific suppression of delayed hypersensitivity skin reactions to collagen in guinea-pigs after immunization with collagen and Freund's incomplete adjuvant.用胶原蛋白和弗氏不完全佐剂免疫后，对豚鼠中胶原蛋白迟发型超敏皮肤反应的特异性抑制。
Immunology. 1976 Jul;31(1):87-94.
7
The influence of cyclophosphamide on antibody formation in the mouse.环磷酰胺对小鼠抗体形成的影响。
Ann Immunol (Paris). 1975 Apr;126(3):267-79.
8
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Immunology. 1976 Jun;30(6):929-33.
9
Suppression of rat adjuvant disease by cyclophosphamide pretreatment: evidence for an antibody mediated component in the pathogenesis of the disease.环磷酰胺预处理对大鼠佐剂性疾病的抑制作用：该疾病发病机制中抗体介导成分的证据。
Clin Exp Immunol. 1978 Apr;32(1):86-96.
10
In vivo macrophage suppression of delayed hypersensitivity in the guinea-pig.豚鼠体内巨噬细胞对迟发型超敏反应的抑制作用。
Immunology. 1982 Dec;47(4):709-16.

引用本文的文献

1
Modulation of the immune system in the mouse. 1. Drug administration prior to antigen sensitization.小鼠免疫系统的调节。1. 抗原致敏前给药。
Agents Actions. 1980 Sep;10(4):378-88. doi: 10.1007/BF01971444.
2
Activation of human B lymphocytes. XII. Differential effects of in vitro cyclophosphamide on human lymphocyte subpopulations involved in B-cell activation.人B淋巴细胞的激活。十二。体外环磷酰胺对参与B细胞激活的人淋巴细胞亚群的不同作用。
Immunology. 1980 Mar;39(3):391-7.
3
Effects of pulse cyclophosphamide on NZB/W disease.脉冲环磷酰胺对NZB/W疾病的影响。
Immunology. 1981 May;43(1):57-65.
4
The regulation of T cell responses by spontaneously active suppressor cells.自发激活的抑制细胞对T细胞反应的调节。
Clin Exp Immunol. 1982 Nov;50(2):406-15.
5
The influence of cyclophosphamide and 6-mercaptopurine on the IgG1 and IgG2 immune response in guinea-pigs.环磷酰胺和6-巯基嘌呤对豚鼠IgG1和IgG2免疫反应的影响。
Immunology. 1981 Sep;44(1):61-6.
6
Regulation of secondary antibody responses in rodents. I. Potentiation of IgG production by cyclophosphamide.啮齿动物二次抗体反应的调节。I. 环磷酰胺对IgG产生的增强作用。
Clin Exp Immunol. 1979 Jul;37(1):89-97.
7
Contact sensitivity and the DNA response in mice to high and low doses of oxazolone: low dose unresponsiveness following painting and feeding and its prevention by pretreatment with cyclophosphamide.小鼠对高剂量和低剂量恶唑酮的接触敏感性及DNA反应：涂抹和喂食后的低剂量无反应性及其通过环磷酰胺预处理的预防
Immunology. 1979 Mar;36(3):449-59.
8
The effect of cyclophosphamide pretreatment on B-cell stimulation: dissociation of action on homocytotropic antibody and other B-cell functions.环磷酰胺预处理对B细胞刺激的影响：对亲同种细胞抗体及其他B细胞功能作用的解离
Immunology. 1978 Jan;34(1):115-21.

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IMMUNOLOGIC UNRESPONSIVENESS IN THE ADULT GUINEA PIG. I. SUPPRESSION OF DELAYED HYPERSENSITIVITY AND ANTIBODY FORMATION TO PROTEIN ANTIGENS.成年豚鼠的免疫无反应性。I. 对蛋白质抗原的迟发型超敏反应和抗体形成的抑制
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PREPARATION OF PURIFIED ANTI-2,4-DINITROPHENYL ANTIBODIES.纯化抗2,4-二硝基苯基抗体的制备
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Selective depletion of lymphoid tissue by cyclophosphamide.用环磷酰胺选择性地消耗淋巴组织。
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Rosette-forming cells and the immunological response after DNCB, DNP-carrier and oxazolone sensitization.二硝基氯苯、二硝基苯载体及恶唑酮致敏后玫瑰花结形成细胞与免疫反应
Immunology. 1974 Feb;26(2):269-80.
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Effects of cyclophosphamide on lymphoid tissues labelled with 5-iodo-2-deoxyuridine- 125 I and 51 Cr.环磷酰胺对用5-碘-2-脱氧尿苷-125I和51Cr标记的淋巴组织的影响。
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Potentiation of T-cell-mediated immunity by selective suppression of antibody formation with cyclophosphamide.通过环磷酰胺选择性抑制抗体形成增强T细胞介导的免疫
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B-cell suppression of delayed hypersensitivity reactions.B细胞对迟发型超敏反应的抑制作用。
Nature. 1974 Oct 11;251(5475):550-1. doi: 10.1038/251550a0.
8
Further studies on B-lymphocyte suppression in delayed hypersensitivity, indicating a possible mechanism for Jones-Mote hypersensitivity.对迟发型超敏反应中B淋巴细胞抑制作用的进一步研究，揭示了琼斯-莫特超敏反应的一种可能机制。
Immunology. 1973 Apr;24(4):751-8.
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Reversal of immunological tolerance by cyclophosphamide through inhibition of suppressor cell activity.环磷酰胺通过抑制抑制性细胞活性逆转免疫耐受。
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10
A buffered chromic chloride method of attaching antigens to red cells: use in haemagglutination.一种将抗原附着于红细胞的缓冲氯化铬方法：用于血凝反应。
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B细胞刺激与迟发型超敏反应之间的关系。环磷酰胺预处理对抗体产生的影响。

The relation between B-cell stimulation and delayed hypersensitivity. The effect of cyclophosphamide pretreatment on antibody production.

作者信息

Noble B, Parker D, Scheper R J, Turk J L

出版信息

Immunology. 1977 Jun;32(6):885-91.

PMID:142067
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445440/
Abstract

Cyclophosphamide (CY), which can enhance some forms of delayed-type hypersensitivity if given 3 days before immunization, is also a potent suppressor of most antibody mediated 4-h skin reactions to protein antigens. However many haemagglutinating antibodies, which are present in serum at the time of skin testing, are not similarly suppressed. Antibody titres in some sera recovered from CY-pretreated guinea-pigs differ little from titres in control sera. This resistance to CY suggests that long-lived precursors characterize the B-cell lines that produce many haemagglutinating antibodies, whereas the CY-sensitive precursors of skin reactive antibodies, which mediate Arthus-type reactions, are probably rapidly dividing, short-lived cells. Furthermore, the novel appearance of BGG antibodies in sera from CY-pretreated animals immunized with DNP50-BGG indicates that haemagglutinating antibody responses to some antigens are regulated by CY-sensitive mechanisms.

摘要

环磷酰胺（CY），如果在免疫前3天给予，可增强某些形式的迟发型超敏反应，它也是大多数抗体介导的对蛋白质抗原的4小时皮肤反应的强效抑制剂。然而，皮肤试验时血清中存在的许多血凝抗体并未受到类似的抑制。从经CY预处理的豚鼠中回收的一些血清中的抗体滴度与对照血清中的滴度差异不大。对CY的这种抗性表明，产生许多血凝抗体的B细胞系的特征是长寿前体，而介导阿瑟斯型反应的皮肤反应性抗体的CY敏感前体可能是快速分裂、寿命短的细胞。此外，在用DNP50-BGG免疫的经CY预处理动物的血清中BGG抗体的新出现表明，对某些抗原的血凝抗体反应受CY敏感机制调节。