Beer M, Landschütz W, Meininger M, Seyfarth T, Viehrig M, Sandstede J, Pabst T, Kenn W, Horn M, Harre K, von Kienlin M, Neubauer S, Hahn D
Institut für Röntgendiagnostik, Universität Würzburg.
Rofo. 1999 Jul;171(1):65-8. doi: 10.1055/s-1999-9896.
A quantitative 31P-MR-spectroscopic technique was used to assess the energy metabolism in healthy and diseased myocardium.
31P spectra were acquired on a 1.5 T scanner using a 3D-chemical shift imaging technique. Based on the anatomical information provided by 1H images, SLOOP (Spatial Localization with Optimal Pointspread Function) allows to obtain spectra from defined compartments. With SLOOP a free voxel shape with adaption to anatomic structures, e.g. the myocardium, is possible. Absolute values for phosphocreatine (PCr) and adenosine triphosphate (ATP) were determined using an external standard.
31P-spectra showed only minimal contamination by surrounding tissue. The standard deviation for the determined values of healthy volunteers was low. Compared to healthy volunteers, reduced PCr and ATP concentrations were seen for dilative cardiomyopathies and coronary artery disease and unchanged concentrations were observed for hypertensive heart disease.
31P-MR spectroscopy with SLOOP allows a non-invasive, quantitative analysis of cardiac energy metabolism.
采用定量31P磁共振波谱技术评估健康和患病心肌的能量代谢。
使用3D化学位移成像技术在1.5T扫描仪上采集31P谱。基于1H图像提供的解剖学信息，SLOOP（具有最佳点扩散函数的空间定位）可从特定区域获取谱。通过SLOOP能够获得适应解剖结构（如心肌）的自由体素形状。使用外标确定磷酸肌酸（PCr）和三磷酸腺苷（ATP）的绝对值。
31P谱显示周围组织的污染极小。健康志愿者测定值的标准差较低。与健康志愿者相比，扩张型心肌病和冠状动脉疾病患者的PCr和ATP浓度降低，而高血压性心脏病患者的浓度未变。
采用SLOOP的31P磁共振波谱可对心脏能量代谢进行无创定量分析。
