Schindler R, Krahe T, Neubauer S, Hillenbrand H, Entzeroth C, Horn M, Lackner K, Ertl G
Institut für Röntgendiagnostik, Universität Würzburg.
Rofo. 1992 Nov;157(5):452-7. doi: 10.1055/s-2008-1033041.
The T1 relaxation times of the phosphorus metabolites in human heart muscle measurable by 31P-MR spectra were determined in 12 individuals using a 1.5 Tesla system. Several spectra were recorded consecutively with a pulse repetition time of 1.6 s to 24 s. The T1 times of creatine phosphate (CP), of gamma-, alpha-, beta-adenosintriphosphate (ATP), 2,3-diphosphoglycerate (2,3-DPG) together with anorganic phosphate) and phosphodiester (PDE) showed mean measurements of 6.1 +/- 0.5, 5.4 +/- 0.5, 5.0 +/- 0.5, 5.8 +/- 1.0, 7.6 +/- 1.0, and 5.0 +/- 1.0 s (M +/- SE). The accuracy of the ISIS technique was tested with a special phantom. T1 times were also measured in standard solutions (20 mM CP, 10 mM ATP); CP was 8.7 +/- 0.2 s and gamma-ATP was 9.9 +/- 0.7 s. Corrections for partially saturated 31P-MR spectra--at least for CP/ATP ratios--are relatively small.
使用1.5特斯拉系统对12名个体测定了通过31P-MR谱可测量的人体心肌中磷代谢物的T1弛豫时间。以1.6秒至24秒的脉冲重复时间连续记录了几个谱。磷酸肌酸（CP）、γ-、α-、β-三磷酸腺苷（ATP）、2,3-二磷酸甘油酸（2,3-DPG）（连同无机磷酸盐）和磷酸二酯（PDE）的T1时间显示平均测量值分别为6.1±0.5、5.4±0.5、5.0±0.5、5.8±1.0、7.6±1.0和5.0±1.0秒（平均值±标准误）。使用特殊模型测试了ISIS技术的准确性。还在标准溶液（20 mM CP，10 mM ATP）中测量了T1时间；CP为8.7±0.2秒，γ-ATP为9.9±0.7秒。对部分饱和的31P-MR谱的校正——至少对于CP/ATP比率——相对较小。
