Masters Steedman S, Middaugh S J, Kee W G, Carson D S, Harden R N, Miller M C
Department of Pharmacy Services, Medical University of South Carolina, Charleston 29425.
Clin J Pain. 1992 Sep;8(3):204-14.
Medication use is an important consideration in chronic-pain rehabilitation programs (CPRPs). However, it is difficult to quantify this aspect of chronic-pain treatment, because patients often take multiple medications that can differ by pharmacological class as well as dosage level. The Medication Quantification Scale (MQS) provides a method for quantifying medication use in patients with chronic, nonmalignant pain. Scores are calculated for each medication based on weights assigned by medication class and dosage level, and these scores are summed to provide a quantitative index of total medication usage suitable for statistical analysis. The method for calculating MQS scores is illustrated, and research data on MQS reliability and validity are presented. Interrater reliability was rho = 0.985 (p less than 0.0001) for 30 MQS scores calculated by two clinicians. MQS scores for 88 patients correlated well with the clinical judgment of 12 health care professionals (mean rho = 0.755, p less than 0.0001). The MQS scores for 60 chronic-pain patients (30 treated in a CPRP and 30 untreated) were obtained at two time points: evaluation and 1-year follow-up. A two (groups) by two (time points) analysis of variance yielded a significant group-by-time interaction (F = 8.82, p less than 0.0043). Treated patients decreased their medication intake significantly (p less than 0.0001), whereas untreated patients did not (p greater than 0.57). The MQS offers a reliable and valid method for quantifying medication usage in chronic-pain patients.
药物使用是慢性疼痛康复项目（CPRPs）中的一个重要考量因素。然而，量化慢性疼痛治疗的这一方面很困难，因为患者通常服用多种药物，这些药物在药理类别和剂量水平上可能存在差异。药物量化量表（MQS）提供了一种量化慢性非恶性疼痛患者药物使用情况的方法。根据药物类别和剂量水平分配的权重为每种药物计算得分，这些得分相加可提供一个适合统计分析的药物总使用量的定量指标。文中说明了计算MQS得分的方法，并展示了关于MQS可靠性和有效性的研究数据。两位临床医生计算的30个MQS得分的评分者间信度为rho = 0.985（p小于0.0001）。88名患者的MQS得分与12名医疗保健专业人员的临床判断相关性良好（平均rho = 0.755，p小于0.0001）。在两个时间点获取了60名慢性疼痛患者（30名在CPRP中接受治疗，30名未接受治疗）的MQS得分：评估时和1年随访时。两因素（组）×两因素（时间点）方差分析产生了显著的组×时间交互作用（F = 8.82，p小于0.0043）。接受治疗的患者药物摄入量显著减少（p小于0.0001），而未接受治疗的患者则没有（p大于0.57）。MQS为量化慢性疼痛患者的药物使用情况提供了一种可靠且有效的方法。
