Tokunaga A, Nishi K, Matsukura N, Tanaka N, Onda M, Shirota A, Asano G, Hayashi K
Cancer. 1986 Apr 1;57(7):1376-9. doi: 10.1002/1097-0142(19860401)57:7<1376::aid-cncr2820570722>3.0.co;2-z.
Cancerous tissue from 86 patients with primary gastric cancer were examined for the presence of receptors for estrogen (ER) and progesterone (PgR). ER and PgR were present in 8 (15.4%) and 5 (9.6%), respectively, of 52 male patients, 9 (26.6%) and 7 (20.6%), respectively, of 34 female patients, a total of 17 (19.8%) and 12 (14.0%), respectively. One male patient (1.9%) and 4 female patients (11.8%) had both ER and PgR, and 40 male (76.9%) and 22 female patients (64.7%) showed no ER or PgR. The binding activity ranged from 6 to 200 fmol/mg protein for estradiol and from 5 to 58 fmol/mg protein for progesterone. ER- and/or PgR-positive cases were characterized grossly as Borrmann type 4, and microscopically as diffuse type with scirrhous growth pattern. The presence of ER and/or PgR in some gastric cancers indicates the possibility that sex hormonal factors are involved in these tumors.
对86例原发性胃癌患者的癌组织进行雌激素（ER）和孕激素（PgR）受体检测。52例男性患者中，ER和PgR阳性分别为8例（15.4%）和5例（9.6%）；34例女性患者中，ER和PgR阳性分别为9例（26.6%）和7例（20.6%），总体ER和PgR阳性分别为17例（19.8%）和12例（14.0%）。1例男性患者（1.9%）和4例女性患者（11.8%）同时存在ER和PgR，40例男性患者（76.9%）和22例女性患者（64.7%）ER或PgR均为阴性。雌二醇的结合活性范围为6至200 fmol/mg蛋白，孕酮的结合活性范围为5至58 fmol/mg蛋白。ER和/或PgR阳性病例大体表现为Borrmann 4型，显微镜下表现为弥漫型伴硬癌生长方式。部分胃癌中存在ER和/或PgR表明性激素因素可能参与了这些肿瘤的发生。
