Melchior J C, Rigaud D, Colas-Linhart N, Rozen R, Fantino M, Apfelbaum M
INSERM U. 286, Medical School X. Bichat, Paris, France.
Pharmacol Biochem Behav. 1990 Apr;35(4):885-8. doi: 10.1016/0091-3057(90)90375-r.
The combined effects of an intragastric load of glucose compared to water and of naltrexone compared to placebo were tested on preference for sucrose in six anorectic patients. While in normal subjects, glucose-induced negative allesthesia is known to disappear upon loss of weight, it persisted in anorexia nervosa (AN) despite a major weight loss; furthermore, in contrast with its effects in normoponderal subjects, naltrexone at the dose of 25 mg did not decrease the preference for sucrose nor did it enhance glucose-induced allesthesia. Basal plasma beta endorphin level determined by radioimmunoassay was higher in AN than in normal subjects (75 +/- 6.1 pmoles/l vs. 13 +/- 3.8 pmoles/l) (p less than 0.001). It is suggested that a decrease in endogenous system opiate activity might be associated with food refusal and body weight loss in anorexia nervosa.
在六名神经性厌食症患者中，测试了与摄入水相比，胃内负荷葡萄糖以及与服用安慰剂相比，服用纳曲酮对蔗糖偏好的综合影响。虽然在正常受试者中，已知体重减轻时葡萄糖诱导的负性味觉减退会消失，但在神经性厌食症（AN）患者中，尽管体重大幅减轻，这种现象仍持续存在；此外，与对体重正常受试者的作用相反，25毫克剂量的纳曲酮既没有降低对蔗糖的偏好，也没有增强葡萄糖诱导的味觉减退。通过放射免疫测定法测定的基础血浆β-内啡肽水平在AN患者中高于正常受试者（75±6.1皮摩尔/升对13±3.8皮摩尔/升）（p<0.001）。提示内源性阿片系统活性降低可能与神经性厌食症患者的食物拒绝和体重减轻有关。
