Tomoda M, Asahara H, Gonda R, Takada K
Kyoritsu College of Pharmacy, Tokyo, Japan.
Chem Pharm Bull (Tokyo). 1992 Aug;40(8):2219-21. doi: 10.1248/cpb.40.2219.
The controlled Smith degradation of MVS-VI, the major acidic polysaccharide having remarkable anti-complementary activity isolated from the seeds of Malva verticillata L., was performed. Methylation analysis of both the primary and the secondary Smith degradation products indicated that the core structural features of MVS-VI include a backbone chain composed of beta-1,3-linked D-galactose residues. The majority of galactose units in the backbone carry side chains composed of beta-1,3- and beta-1,6-linked D-galactosyl residues at position 6. The controlled Smith degradation products showed considerable anti-complementary activity.
对从锦葵种子中分离出的具有显著抗补体活性的主要酸性多糖MVS-VI进行了可控的史密斯降解。对一级和二级史密斯降解产物的甲基化分析表明，MVS-VI的核心结构特征包括由β-1,3-连接的D-半乳糖残基组成的主链。主链中的大多数半乳糖单元在6位带有由β-1,3-和β-1,6-连接的D-半乳糖基残基组成的侧链。可控的史密斯降解产物表现出相当大的抗补体活性。
