Mierdel P, Zenker H J, Marré E
Eye Clinic, Medical Academy Carl Gustav Carus, Dresden, Germany.
Int Ophthalmol. 1992 Sep;16(4-5):211-4. doi: 10.1007/BF00917963.
Pattern reversals with a ramp-like temporal course evoke transient pattern electroretinograms (PERG) that are delayed and attenuated in comparison with responses evoked by a step-like course (abrupt pattern reversals). This delay depends on the reversal time and probably represents a measure for temporal characteristics of the activated retinal structures. A pattern reversal stimulator with adjustable reversal periods (matrix of 8 x 14 rectangular red light emitting diodes, element size 2 degrees x 1 degree, stimulus area 16 degrees x 14 degrees) was used to record transient PERGs from 20 glaucomatous eyes with early or moderate visual field damages (measured with computer perimetry). The q-wave (P1) amplitude difference between the glaucoma group and normal subjects with step-like reversal stimulation was not significant (P = 0.23). On the other hand, a highly significant separation (P < 0.0001) between both groups was possible using the P1 latency at ramp-like stimulation or the response latency shift between step and ramp-like stimulation (Pattern reversal time, 30 ms).
具有斜坡状时间进程的模式反转会诱发瞬态图形视网膜电图（PERG），与由阶梯状进程（突然的模式反转）诱发的反应相比，该图形视网膜电图会延迟且减弱。这种延迟取决于反转时间，可能代表了对被激活的视网膜结构时间特征的一种测量。使用具有可调节反转周期的模式反转刺激器（8×14矩形红色发光二极管矩阵，元件尺寸2度×1度，刺激区域16度×14度），从20只患有早期或中度视野损害（通过计算机视野计测量）的青光眼眼中记录瞬态PERG。青光眼组与采用阶梯状反转刺激的正常受试者之间的q波（P1）振幅差异不显著（P = 0.23）。另一方面，使用斜坡状刺激时的P1潜伏期或阶梯状与斜坡状刺激之间的反应潜伏期偏移（模式反转时间，30毫秒），两组之间可以实现高度显著的区分（P < 0.0001）。
