Bielik M, Zwas F, Shin D H, Tsai C S
Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI 38201.
Graefes Arch Clin Exp Ophthalmol. 1991;229(5):401-5. doi: 10.1007/BF00166299.
Pattern electroretrinography (PERG) was performed in 33 patients with chronic open-angle glaucoma (COAG), 18 ocular hypertensive (OH) patients, and 24 normal subjects. COAG patients exhibited significantly lower PERG amplitudes than did normal subjects (P8rps = 0.025; P16rps less than 0.0001). The OH patients fell into two distinct groups: those with normal PERG scores and those with lower than normal scores. OH patients with PERG scores significantly lower than control values demonstrated significantly larger cup-to-disc ratios (P = 0.002) and higher initial intraocular pressures (IOPs) than did OH patients with normal PERG scores (P = 0.021). In the 11 OH patients in whom spectral sensitivity measurement was available, statistically significant correlations were found between the blue-cone sensitivity loss and the PERG amplitude (r8rps = 0.772, P8rps = 0.0053 and r16rps = 0.699, P16rps = 0.0167, respectively. Our results demonstrate reduced PERG amplitude in high-risk OH patients and further illustrate the correlation between PERG amplitude and blue-cone spectral sensitivity in OH subjects. Confirmation of the roles of PERG and spectral sensitivity in the detection of early glaucoma requires longitudinal study.
对33例慢性开角型青光眼（COAG）患者、18例高眼压症（OH）患者和24名正常受试者进行了图形视网膜电图（PERG）检查。COAG患者的PERG振幅显著低于正常受试者（P8rps = 0.025；P16rps < 0.0001）。OH患者分为两组：PERG评分正常的患者和评分低于正常的患者。PERG评分显著低于对照值的OH患者，其杯盘比显著更大（P = 0.002），初始眼压（IOP）也高于PERG评分正常的OH患者（P = 0.021）。在11例可进行光谱敏感度测量的OH患者中，发现蓝锥敏感度损失与PERG振幅之间存在统计学显著相关性（r8rps = 0.772，P8rps = 0.0053；r16rps = 0.699，P16rps = 0.0167）。我们的结果表明高危OH患者的PERG振幅降低，并进一步说明了OH受试者中PERG振幅与蓝锥光谱敏感度之间的相关性。需要进行纵向研究以证实PERG和光谱敏感度在早期青光眼检测中的作用。
