Resnik R, Brink G W, Wilkes M
J Clin Invest. 1979 Jun;63(6):1133-6. doi: 10.1172/JCI109406.
The effect of nicotine on uterine blood flow, uterine vascular resistance, and plasma catecholamine concentration was studied in chronically catheterized pregnant sheep equipped with electromagnetic flow probes. The systemic administration of nicotine (14--32 micrograms/kg body wt per min) resulted in a 44% reduction in uterine blood flow (P less than 0.001) and a 203% increase in uterine vascular resistance. Both responses were inhibited by pretreatment with the alpha blocker, phentolamine. Arterial plasma concentrations of norepinephrine and epinephrine, measured by a single isotopic radioenzymatic assay, rose (from 117.9 +/- 6.7 to 201.8 +/- 13.3 pg/ml, P less than 0.001; and from 71.6 +/- 4.5 to 124.1 +/- 8.4 pg/ml, P less than 0.001, respectively) during nicotine infusion. The findings suggest that nicotine exerts a deleterious effect on uterine blood flow mediated through the release of catecholamines.
在装有电磁血流探头的慢性插管妊娠绵羊中，研究了尼古丁对子宫血流量、子宫血管阻力和血浆儿茶酚胺浓度的影响。尼古丁全身给药（每分钟14 - 32微克/千克体重）导致子宫血流量减少44%（P < 0.001），子宫血管阻力增加203%。这两种反应均被α受体阻滞剂酚妥拉明预处理所抑制。通过单一同位素放射酶法测定，在输注尼古丁期间，动脉血浆去甲肾上腺素和肾上腺素浓度升高（分别从117.9±6.7皮克/毫升升至201.8±13.3皮克/毫升，P < 0.001；从71.6±4.5皮克/毫升升至124.1±8.4皮克/毫升，P < 0.001）。这些发现表明，尼古丁通过释放儿茶酚胺对子宫血流量产生有害影响。
