• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

[硫胺素焦磷酸酯和二氯醋酸钠对苯乙双胍诱导的离体灌注大鼠胰腺乳酸和胰岛素分泌增加的影响]

[Effects of thiamine pyrophosphate and sodium dichloroacetate on the increase of lactate and insulin outputs induced by phenformin on the isolated and perfused rat pancreas].

作者信息

Loubatières A L, Loubatières-Mariani M M, Alric R, Blayac J P, Valette G

出版信息

C R Seances Soc Biol Fil. 1977;171(1):155-60.

PMID:143313
Abstract

Thiamine pyrophosphate and sodium dichloroacetate, substances which promote the aerobic metabolism of pyruvate, reduce the increase in lactate output induced by phenformin (100 mg/l) on the isolated and perfused rat pancreas. Both substances provoke a decrease in insulin secretion produced by phenformin.

摘要

硫胺素焦磷酸和二氯醋酸钠可促进丙酮酸的有氧代谢，它们能减少苯乙双胍（100毫克/升）对离体灌注大鼠胰腺所诱导的乳酸产量增加。这两种物质都会使苯乙双胍所引起的胰岛素分泌减少。

相似文献

1
[Effects of thiamine pyrophosphate and sodium dichloroacetate on the increase of lactate and insulin outputs induced by phenformin on the isolated and perfused rat pancreas].[硫胺素焦磷酸酯和二氯醋酸钠对苯乙双胍诱导的离体灌注大鼠胰腺乳酸和胰岛素分泌增加的影响]
C R Seances Soc Biol Fil. 1977;171(1):155-60.
2
Is lactate involved in phenformin-induced insulin secretion?乳酸是否参与苯乙双胍诱导的胰岛素分泌？
Horm Metab Res. 1979 Feb;11(2):95-9. doi: 10.1055/s-0028-1092687.
3
[Correlation between lactate output and insulin secretion of the isolated perfused rat pancreas under the influence of high concentrations of phenformin].
C R Seances Soc Biol Fil. 1976;170(4):828-32.
4
Do metformin and phenformin potentiate differently B-cell response to high glucose? An in vitro study on isolated rat pancreas.
Diabete Metab. 1991 Jan-Feb;17(1):19-28.
5
Evidence for a role of exogenous or endogenous hyperlactatemia in insulin secretion in the dog.外源性或内源性高乳酸血症在犬胰岛素分泌中作用的证据。
J Physiol (Paris). 1979;75(8):881-6.
6
Inhibition of lactate glucogneogenesis in rat kidney by dichloroacetate.二氯乙酸对大鼠肾脏中乳酸糖异生的抑制作用。
Biochem J. 1978 Mar 15;170(3):551-60. doi: 10.1042/bj1700551.
7
[Sodium dichloracetate: its application to the therapeutics of experimental hyperiactatemia (author's transl)].二氯醋酸钠：其在实验性高乳酸血症治疗中的应用（作者译）
Diabete Metab. 1978 Mar;4(1):5-11.
8
[Endogenous hyperlactatemia and insulin secretion].[内源性高乳酸血症与胰岛素分泌]
C R Seances Soc Biol Fil. 1978;172(1):161-6.
9
[Effect of cocarboxylase on hyperlactatemia and hyperpyruvicemia induced by phenformin in dogs].
C R Seances Soc Biol Fil. 1975;169(1):121-5.
10
Effects of dichloroacetate on the lactate/pyruvate ratio and on aspartate and leucine metabolism in cultured rat skeletal muscle cells.二氯乙酸对培养的大鼠骨骼肌细胞中乳酸/丙酮酸比值以及天冬氨酸和亮氨酸代谢的影响。
Biochem Pharmacol. 1983 Jan 1;32(1):97-100. doi: 10.1016/0006-2952(83)90659-7.

引用本文的文献

1
Metformin and Micronutrient Status in Type 2 Diabetes: Does Polypharmacy Involving Acid-Suppressing Medications Affect Vitamin B12 Levels?2型糖尿病患者的二甲双胍与微量营养素状况：联用抑酸药物的多重用药是否会影响维生素B12水平？
Diabetes Metab Syndr Obes. 2020 Jun 18;13:2093-2108. doi: 10.2147/DMSO.S237454. eCollection 2020.