Loubatières A L, Loubatières-Mariani M M, Alric R, Blayac J P, Valette G
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Thiamine pyrophosphate and sodium dichloroacetate, substances which promote the aerobic metabolism of pyruvate, reduce the increase in lactate output induced by phenformin (100 mg/l) on the isolated and perfused rat pancreas. Both substances provoke a decrease in insulin secretion produced by phenformin.
硫胺素焦磷酸和二氯醋酸钠可促进丙酮酸的有氧代谢,它们能减少苯乙双胍(100毫克/升)对离体灌注大鼠胰腺所诱导的乳酸产量增加。这两种物质都会使苯乙双胍所引起的胰岛素分泌减少。