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[硫胺素焦磷酸酯和二氯醋酸钠对苯乙双胍诱导的离体灌注大鼠胰腺乳酸和胰岛素分泌增加的影响]

[Effects of thiamine pyrophosphate and sodium dichloroacetate on the increase of lactate and insulin outputs induced by phenformin on the isolated and perfused rat pancreas].

作者信息

Loubatières A L, Loubatières-Mariani M M, Alric R, Blayac J P, Valette G

出版信息

C R Seances Soc Biol Fil. 1977;171(1):155-60.

PMID:143313
Abstract

Thiamine pyrophosphate and sodium dichloroacetate, substances which promote the aerobic metabolism of pyruvate, reduce the increase in lactate output induced by phenformin (100 mg/l) on the isolated and perfused rat pancreas. Both substances provoke a decrease in insulin secretion produced by phenformin.

摘要

硫胺素焦磷酸和二氯醋酸钠可促进丙酮酸的有氧代谢,它们能减少苯乙双胍(100毫克/升)对离体灌注大鼠胰腺所诱导的乳酸产量增加。这两种物质都会使苯乙双胍所引起的胰岛素分泌减少。

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