Loubatieres A, Valette G, Ribes G, Loubatieres-Mariani M M, Rondot A M
Diabete Metab. 1978 Mar;4(1):5-11.
Different types of experimental hyperlactatemia and hyperpyruvicemia with or without lowering of blood pH were induced in anesthetized dogs. The initially studied experimental model was the hyperlactatemia and hyperpyruvicemia with lowering of blood pH induced by the intraduodenal administration of high doses of phenformin. Intravenous perfusion of sodium dichloroacetate (150 mg/kg infused during 20 minutes), which acts on the enzymatic complex of pyruvate dehydrogenase, reduced the hyperiactatemia and hyperpyruvicemia with or without acidosis provoked by phenformin injected intraduodenally (30 mg/kg), by intense muscular work, by hypoxia or by continous perfusion or adrenaline. Exogenous or endogenous insulin combined with sodium dichloracetate reduced the hyperlactatemia and hyperpyruvicemia as well as the changes in blood pH provoked by phenformin, more strongly than did sodium dichloroacetate alone. These findings have been confirmed in the conscious dog.
在麻醉犬身上诱发了不同类型的实验性高乳酸血症和高丙酮酸血症，伴有或不伴有血液pH值降低。最初研究的实验模型是通过十二指肠内给予高剂量苯乙双胍诱导的伴有血液pH值降低的高乳酸血症和高丙酮酸血症。静脉灌注二氯醋酸钠（20分钟内输注150mg/kg），其作用于丙酮酸脱氢酶酶复合物，可减轻由十二指肠内注射苯乙双胍（30mg/kg）、剧烈肌肉运动、缺氧或持续灌注肾上腺素所引发的伴有或不伴有酸中毒的高乳酸血症和高丙酮酸血症。外源性或内源性胰岛素与二氯醋酸钠联合使用，比单独使用二氯醋酸钠更能有效减轻苯乙双胍所引发的高乳酸血症、高丙酮酸血症以及血液pH值变化。这些发现已在清醒犬身上得到证实。
