Houlston R S, Lemoine L, McCarter E, Harrington S, MacDermot K, Hinton J, Berger L, Slack J
Department of Clinical Genetics, Royal Free Hospital, School of Medicine, London.
J Med Genet. 1992 Oct;29(10):691-4. doi: 10.1136/jmg.29.10.691.
Family history is the major risk factor in the aetiology of breast cancer. Breast screening is currently available to women from the age of 50 to 64 through the National Breast Screening Programme. There is, however, an equivalent risk of developing breast cancer below 50 for first degree relatives of women diagnosed with breast cancer premenopausally. We have estimated the risk of breast cancer for relatives of women affected at different ages and used these to establish a family cancer clinic offering breast screening based on individual risk. In three years we have seen 851 patients. Compliance for annual radiology was in excess of 83% over this period and of five cancers detected one had a lump at presentation, two developed interval breast lumps, and two were asymptomatic.
家族病史是乳腺癌病因中的主要风险因素。目前，通过国家乳腺癌筛查计划，50至64岁的女性可接受乳腺癌筛查。然而，对于在绝经前被诊断为乳腺癌的女性的一级亲属，在50岁以下患乳腺癌的风险相当。我们估计了不同年龄受影响女性亲属患乳腺癌的风险，并据此设立了一家家族癌症诊所，根据个体风险提供乳腺癌筛查。三年来，我们共接待了851名患者。在此期间，年度放射检查的依从率超过83%，检测出的5例癌症中，1例在就诊时有肿块，2例在筛查间隔期出现乳腺肿块，2例无症状。
