Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China.
Key Laboratory for Prevention and Control of Avian Influenza and Other Major Poultry Diseases, Ministry of Agriculture and Rural Affairs, Guangzhou 510640, China.
Biomed Res Int. 2022 Aug 28;2022:1635373. doi: 10.1155/2022/1635373. eCollection 2022.
In recent years, an infection in geese caused by goose astrovirus (GAstV) has repeatedly occurred in coastal areas of China and rapidly spread to inland provinces. The infection is characterized by joint and visceral gout and is fatal. The disease has caused huge economic losses to China's goose industry. GAstV is a nonenveloped, single-stranded, positive-sense RNA virus. As it is a novel virus, there is no specific classification. Here, we review the current understanding of GAstV. The virus structure, isolation, diagnosis and detection, innate immune regulation, and transmission route are discussed. In addition, since GAstV can cause gout in goslings, the possible role of GAstV in gout formation and uric acid metabolism is discussed. We hope that this review will inform researchers to rapidly develop effective methods to prevent and treat this disease.
近年来，鹅源星状病毒（GAstV）引起的感染在中国沿海地区反复发生，并迅速蔓延至内陆省份。该感染以关节和内脏痛风为特征，具有致命性。该疾病给中国的鹅业造成了巨大的经济损失。GAstV 是一种无包膜、单链、正链 RNA 病毒。由于它是一种新型病毒，因此没有特定的分类。在这里，我们综述了对 GAstV 的现有认识。讨论了病毒结构、分离、诊断和检测、先天免疫调节和传播途径。此外，由于 GAstV 可引起雏鹅痛风，因此讨论了 GAstV 在痛风形成和尿酸代谢中的可能作用。我们希望本综述能为研究人员提供信息，以便迅速开发出预防和治疗这种疾病的有效方法。
