Pochi P E, Strauss J S, Downing D T
J Invest Dermatol. 1977 Nov;69(5):485-9. doi: 10.1111/1523-1747.ep12511753.
Fifty-two children, age 5-10, from acne-prone families, were studied for a period of 1 year to examine the interrelationship between sebum, acne, pubertal development, and urinary steroid excretion. In each of the subjects, 30 boys and 22 girls, the composition of forehead skin lipid was determined 4 times yearly by thin-layer chromatography, with measurement of triglycerides, diglycerides, free fatty acids, wax esters, squalene, cholesterol, and cholesterol esters. Twice yearly, examination was made of the presence or absence of acne, pubertal maturation and the 24-hour urinary excretion of testosterone as determined by radioimmunnoassay, and of total 17-ketosteroids, dehydroepiandrosterone, androsterone, and etiocholanolone, as determined by paper chromatography. The relative amount of sebaceous lipids was positively correlated with age of the subjects (wax esters p less than .001, squalene p less than .05), as was the triglyceride-diglyceride component (p less than .05). No significant correlation was seen with the fatty acids. Acne, primarily comedonal, occurred in 27/52 subjects (15 girls, 12 boys) and was associated with higher sebum values. One-half of the children with acne had no signs of pubertal development. A significantly positive correlation was observed between the relative amount of sebaceous lipid and the urinary excretion of 17-ketosteroids, androsterone, and etiocholanolone in both sexes, and of testosterone and dehydroepiandrosterone in boys. The development of acne in children is an early pubertal event, often evident before other signs of pubertal maturation, and it is associated with an increase in sebum and in the urinary excretion of androgenic steroids.
对52名来自易患痤疮家庭的5至10岁儿童进行了为期1年的研究，以探讨皮脂、痤疮、青春期发育和尿类固醇排泄之间的相互关系。在30名男孩和22名女孩组成的每个研究对象中，每年通过薄层色谱法测定前额皮肤脂质的成分4次，同时测量甘油三酯、甘油二酯、游离脂肪酸、蜡酯、角鲨烯、胆固醇和胆固醇酯。每年两次，检查是否存在痤疮、青春期成熟情况，并通过放射免疫测定法测定睾酮的24小时尿排泄量，以及通过纸色谱法测定总17 - 酮类固醇、脱氢表雄酮、雄酮和本胆烷醇酮。皮脂脂质的相对含量与研究对象的年龄呈正相关（蜡酯p<0.001，角鲨烯p<0.05），甘油三酯 - 甘油二酯成分也是如此（p<0.05）。未发现与脂肪酸有显著相关性。痤疮主要为粉刺型，发生在27/52名研究对象中（15名女孩，12名男孩），且与较高的皮脂值相关。一半患有痤疮的儿童没有青春期发育的迹象。在男女两性中，均观察到皮脂脂质的相对含量与17 - 酮类固醇、雄酮和本胆烷醇酮的尿排泄量之间存在显著正相关，在男孩中与睾酮和脱氢表雄酮的尿排泄量也存在显著正相关。儿童痤疮的发生是青春期早期的一个事件，通常在青春期成熟的其他迹象出现之前就很明显，并且与皮脂增加和雄激素类固醇的尿排泄增加有关。
