Hwang H M, Wang J T, Chiu T H
Department of Anatomy, Chang Gung Medical College, Taoyuan, Taiwan, ROC.
Neurosci Lett. 1992 Jul 20;141(2):227-30. doi: 10.1016/0304-3940(92)90900-r.
Combined actions of GM1 ganglioside molecules and Ca2+ ions on long-term potentiation (LTP) of the hippocampal CA1 synapses were examined in slice preparations. Application of exogenous GM1 ganglioside significantly enhanced LTP. Antigenic blocking of endogenous GM1 ganglioside by applying anti-GM1 antiserum appeared to attenuate LTP. Exogenous GM1 treatment not only antagonized LTP suppression caused by low Ca2+ (1.0 microM) in the perfusion medium, but also amplified LTP at high Ca2+ (5.0 microM) condition. Thus, GM1 may stabilize intracellular calcium levels to enhance synaptic potentiation.
在脑片标本中研究了GM1神经节苷脂分子和Ca2+离子对海马CA1突触长时程增强（LTP）的联合作用。外源性GM1神经节苷脂的应用显著增强了LTP。通过应用抗GM1抗血清对抗内源性GM1神经节苷脂的抗原似乎减弱了LTP。外源性GM1处理不仅拮抗了灌注培养基中低Ca2+（1.0 microM）引起的LTP抑制，而且在高Ca2+（5.0 microM）条件下增强了LTP。因此，GM1可能稳定细胞内钙水平以增强突触增强作用。
