Ugazio A G, Jayakar S D, Marcioni A F, Duse M, Monafo V, Pasquali F, Burgio G R
Eur J Pediatr. 1977 Oct 12;126(3):139-46. doi: 10.1007/BF00442195.
The relationship between the presence of hepatitis B surface antigen (HBsAg) and antibodies to human thyroglobulin (HTgAb) has been studied in 110 subjects with Down's syndrome (DS) from 4 months to 50 years of age and in 122 controls carefully matched for sex, age and socio-environmental conditions. The overall percentage of HBsAg carriers was 22.7 in DS and 6.6 in controls and that of HTgAb-positive subjects was 41.8 in DS and 19.7 in controls. In DS the frequency of HTgAb-positive subjects was very high, even in the youngest age groups in which the percentage of HBsAg carriers was relatively low; the latter thereafter showed a marked increase with age. A positive association between the presence of HBsAg and HTgAb was found only in the oldest age group of DS subjects. It is thus concluded that in DS the high frequency of HTgAb cannot be attributed to chronic hepatitis B virus infection. On the contrary, the presence of HTgAb might well represent an early "marker" of immunodeficiency and increased susceptibility to infection with hepatitis B virus.
对110名年龄从4个月到50岁的唐氏综合征（DS）患者以及122名在性别、年龄和社会环境条件方面精心匹配的对照者，研究了乙肝表面抗原（HBsAg）的存在与人甲状腺球蛋白抗体（HTgAb）之间的关系。DS患者中HBsAg携带者的总体百分比为22.7%，对照者为6.6%；HTgAb阳性受试者的百分比在DS患者中为41.8%，对照者中为19.7%。在DS患者中，HTgAb阳性受试者的频率非常高，即使在最年轻的年龄组中，HBsAg携带者的百分比相对较低；而HBsAg携带者的百分比此后随年龄显著增加。仅在DS患者的最年长年龄组中发现HBsAg和HTgAb的存在呈正相关。因此得出结论，在DS患者中，HTgAb的高频率不能归因于慢性乙肝病毒感染。相反，HTgAb的存在很可能代表免疫缺陷以及对乙肝病毒感染易感性增加的早期“标志物”。
