McMillan B C, Hanson R P, Golubjatnikov R, Sinha S K
Public Health Rep. 1979 Jun;94(3):262-7.
A total of 426 persons were studied in an attempt to more clearly define the high prevalence of hepatitis-B surface antigen (HBsAg) seen among institutionalized persons. HBsAg was found in 63.4 percent of the children and young adults with Down's syndrome (DS) at the Central Wisconsin Center (CWC) and in 45.5 percent of those at the Northern Wisconsin Center (NWC). Significantly more subjects with DS had hepatitis-B antigenemia than age- and sex-matched non-DS institutionalized subjects. Antibody (anti-HBs) to HBsAg was found in 19.5 percent of the DS subjects at CWC and in 38.6 percent of those at NWC. The prevalence of anti-HBs was similar among DS and non-DS institutionalized subjects. None of the noninstitutionalized subjects had HBsAg in their serums and their anti-HBs prevalence was low (2.1 percent). HBsAg was found to persist for at least 10 years in both DS and non-DS institutionalized subjects. However, persistence occurred more frequently among DS subjects. Anti-HBs persisted at least 10 years among non-DS subjects, but DS subjects tended to lose antibody sooner. The study findings indicated that the high prevalence of HBsAg seen in institutionalized DS subjects at CWC and NWC were not related to the age of the subject at admission nor to the duration of institutionalization.
为了更清楚地界定在机构收容人员中发现的高乙肝表面抗原（HBsAg）患病率，共对426人进行了研究。在威斯康星州中部中心（CWC），63.4%的唐氏综合征（DS）儿童和青年中发现了HBsAg，在威斯康星州北部中心（NWC），这一比例为45.5%。与年龄和性别匹配的非DS机构收容人员相比，患有DS的受试者出现乙肝抗原血症的人数明显更多。在CWC，19.5%的DS受试者中发现了针对HBsAg的抗体（抗-HBs），在NWC这一比例为38.6%。DS和非DS机构收容人员中抗-HBs的患病率相似。非机构收容人员的血清中均未检测到HBsAg，其抗-HBs患病率较低（2.1%）。在DS和非DS机构收容人员中，均发现HBsAg至少持续了10年。然而，HBsAg在DS受试者中持续存在的情况更为常见。抗-HBs在非DS受试者中至少持续了10年，但DS受试者的抗体往往更快消失。研究结果表明，在CWC和NWC的机构收容DS受试者中观察到的高HBsAg患病率，与受试者入院时的年龄或机构收容时间无关。
