Barbaro K C, Cardoso J L, Eickstedt V R, Mota I
Centro de Pesquisa e Formação em Imunologia, Instituto Butantan, São Paulo, Brazil.
Toxicon. 1992 Sep;30(9):1117-21. doi: 10.1016/0041-0101(92)90057-c.
The presence and specificity of IgG antibodies produced by patients with loxoscelism were studied. The loxoscelism diagnosis was supported mainly by clinical parameters. A search for IgG antibodies anti-Loxosceles gaucho venom in patients with loxoscelism submitted to serumtherapy showed antibodies in four out of 20 patients. The IgG antibodies were detected as early as 9 days and as late as 120 days after bite. The highest IgG antibody titer was 1:640 and the lowest was 1:80. Immunoblotting tests showed that human anti-L. gaucho IgG antibodies recognize preferentially the components responsible for the dermonecrotic and lethal activities of the venom. A comparison of the clinical picture, the level of serum IgG antibodies and the dose of antivenom administered suggest that there is no relationship between these parameters.
对患有洛矶山蜘蛛毒中毒的患者产生的IgG抗体的存在情况及特异性进行了研究。洛矶山蜘蛛毒中毒的诊断主要依据临床参数。在接受血清疗法的洛矶山蜘蛛毒中毒患者中搜索抗巴西游走蛛毒液的IgG抗体，结果显示20名患者中有4名检测到抗体。IgG抗体最早在咬伤后9天检测到，最晚在120天检测到。最高的IgG抗体滴度为1:640，最低为1:80。免疫印迹试验表明，人抗巴西游走蛛IgG抗体优先识别毒液中负责皮肤坏死和致死活性的成分。对临床症状、血清IgG抗体水平和抗蛇毒血清给药剂量的比较表明，这些参数之间没有关系。
